Case Study

Precision Pays Off: How Targeted Awareness

Drove 3x Rx Lift and Double-Digit ROI for a Biologic Brand 

Challenge

A mid-sized pharmaceutical company faced a critical juncture: their flagship physician-administered biologic brand was nearing loss of exclusivity (LOE), and a new brand extension was preparing to launch. The stakes were high, with two key goals.

Key hurdles included: 

  • Convert existing patients from the LOE product to the new brand.
  • Drive new patient starts among untreated individuals.
But the market was saturated. While the market was crowded with biosimilars and newer branded products, only 3 of the brands were doing DTC advertising, 2 of the brands had a heavy TV presence. The brand needed to cut through the noise with smarter, more efficient patient engagement. Although the client had already mapped the clinical journey, they sought a deeper understanding of audience behaviors—and a way to translate those insights into action across high-impact media channels.
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Hyper-targeted  efficiency driven by a strategy that scales with precision

Solution

Data-Backed Media Planning + Hyperlocal Targeting 

 

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Build Smarter Audiences

Using large-scale healthcare claims data, 

OptimizeRx created custom cohorts based on:

  • Diagnosis relevance and treatment history
  • Specialty engagement and patient characteristics
  • Prior therapy and switching behavior
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Optimize Media Mix & Delivery

Each segment received tailored recommendations for: 

  • Preferred channels and tactics (digital display, OLV, social media, television, etc.)
  • Optimal reach and impression volume
  • Media formats and device preferences
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Activate Micro-Neighborhood Targeting®

Using patented zip-9-level insights, OptimizeRx aligned geographic outreach with claims-based signals indicating high likelihood of treatment initiation or brand conversion. This enabled privacy compliant, hyper-local engagement with deterministic precision.

 

Results

OptimizeRx’s data-driven, behaviorally anchored audience strategy proved its value—outperforming broader DTC efforts and validating that smart campaign planning and targeting isn’t just efficient; it’s transformational. In a highly competitive therapeutic category, this campaign set a new bar for how immunology brands can drive growth through precision media.

Key Outcomes

10:1 to 20:1 ROI 

2.5x to 3x increase in prescription volume 

8-12x ROI maintained