Case Study

AI-Powered Omnichannel HCP Marketing Drives Script Lift for Oral Chemotherapy

Challenge

A pharmaceutical company sought to drive awareness and adoption of an oral chemotherapy drug specifically designed for 3rd/4th line treatment of metastatic colorectal (mCRC), gastric, or GEJ cancers. The primary objective was to quantify the incremental lift in prescribing behavior among healthcare professionals (HCPs) who were exposed to the EHR campaign.
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The campaign sought to reach HCPs at the point-of-care and within their social networks. 

Solution

Partnered with OptimizeRx to implement its AI-powered Dynamic Audience Activation Platform (DAAP). DAAP leverages AI, machine learning, and predictive analytics to identify key HCPs and patients.

 

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AI-Powered Precision Targeting

  • Leveraged AI, machine learning, and predictive analytics to identify key HCPs and patients.
  • Generated weekly prioritized HCP lists based on factors such as identifying patients at the point of disease progression requiring additional treatments within an HCP’s patient panel, and incorporating behavioral data from HCPs who showed script impact after EHR messaging exposure.
  • Ensured the right message reached the right HCPs by predicting patient brand eligibility and upcoming prescribing opportunities, thereby significantly reducing wasted media spend.
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Omnichannel and Workflow-Native Engagement

  • Delivered contextual messages directly in-EHR workflows and across digital channels, including social media, during active clinical decision-making.
  • Leveraged OptimizeRx’s extensive proprietary network of over 300 EHR systems, reaching over 600K verified U.S. prescribers, to provide unparalleled visibility and scale at the moment of patient care.
  • Utilized omnichannel coordination to connect marketing efforts, enabling the synchronization of EHR, social, and programmatic media buys to create "surround sound" for important HCPs and increase reach.
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Real-Time Optimization and Actionable Insights

  • DAAP’s audience prioritization is refreshed every two weeks and generates weekly NPI lists, ensuring outreach remained aligned with care delivery.
  • Workflow-native messaging increased attention and trust by delivering information directly within the HCP’s clinical workflow, specifically the patient chart and prescribing settings, making it actionable.
  • The weekly AI-generated HCP lists could inform all media buys and sales planning, not just EHR engagement, strengthening sales enablement by giving reps intelligent lists aligned with marketing.

 

 

Results

A Pharmaceutical Company partnered with OptimizeRx to achieve a 10.5% Script Lift and 236 New Prescriptions for an Oral Chemotherapy, demonstrating a 7.4:1 ROI. The campaign ran throughout 2025 and is slated to continue based on positive results.

Key Outcomes

+10.5% Absolute NRx Lift among exposed HCPs

236 additional new prescriptions generated (Total Incremental NRx) 

519 total incremental prescriptions (TRx)

459 new-to-brand prescribers engaged