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Vitamin C: Tips For Increasing Your Intake
A new RDA?

According to a recent issue of the Journal of the American Medical Association (JAMA), the National Institutes of Health is taking another look at the Recommended Daily Allowance (RDA) for vitamin C. The current RDA for vitamin C is 60 milligrams per day—about the amount you get from one orange. Due to recent findings on the potential health benefits of this wonder vitamin, the NIH is now considering boosting the RDA to somewhere between 100 and 200 milligrams per day, two to three times the current recommendation.
Why all the hype?

Vitamin C has long been known for its value as an antioxidant. Antioxidants are natural compounds found in many of the foods we eat. The most well known antioxidants are vitamin C, selenium, beta carotene and vitamin E. Antioxidants work by inhibiting toxic substances in the body (also known as "free radicals") which may lead to the development of cancers, heart disease and the aging process. There has been a strong correlation between diets high in fruits and vegetables (which are rich in antioxidants) and reduced risk of chronic diseases. Vitamin C may account for much of this protection. However, we are also finding numerous other compounds within fruits and vegetables, collectively called "phytochemicals", that may also play a preventative role. Phytochemicals are defined simply as chemicals found in plants. They occur naturally in fruits, vegetables, grains, nuts and seeds. These substances, many of which also have an antioxidant effect, may protect our bodies from cellular damage that can lead to cancer and other chronic diseases.

Due to the strong correlation between diets abundant in fruits and vegetables and disease prevention, The National Cancer Institute launched the "5-A-Day" program. The basis of this campaign promotes the intake of a minimum of five fruits and vegetables daily as a good defense against cancer and other diseases. A specific recommendation of this program is to include vitamin C rich fruits and vegetables in the diet each day since vitamin C is a particularly well-researched antioxidant. The mainstay of the program, however, is that by eating five servings of produce daily we can easily take in not just a good dose of vitamin C, but the minimum amount of protective plant chemicals shown to be effective in reducing risk of chronic diseases. Remember, five is the minimum amount. In the case of fruits and veggies it's definitely a situation where more is better!

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Herbicides, Fibrate Drugs May Block Taste Receptors

TUESDAY, Oct. 27 (HealthDay News) -- Some common herbicides and cholesterol drugs block a nutrient-sensing receptor known as T1R3, researchers report.

"Compounds that either activate or block T1R3 receptors could have significant metabolic effects, potentially influencing diseases such as obesity, type II diabetes and metabolic syndrome," study author Dr. Bedrich Mosinger said in a news release. Mosinger is a geneticist at the Monell Chemical Senses Center in Philadelphia.

The receptor helps the body detect sweetness and the savory taste known as umami. It's found on the tongue and also appears to be in the intestine and pancreas.

According to scientists, the receptors notice that nutrients are in food and set off their processing.

In the study, recently published online in the Journal of Medicinal Chemistry, researchers looked at two compounds -- fibrates and phenoxy-herbicides -- to see if they had an effect on the receptors.

Fibrate drugs treat disorders such as high cholesterol and triglycerides. Phenoxy-herbicides, including the commonplace 2,4-D, are used to combat destructive weeds.

The researchers, from Monell and Mount Sinai School of Medicine in New York City, found that both classes of compounds blocked the receptor from activating.

"The metabolic consequences of short- and long-term exposures of humans to phenoxy-herbicides are unknown," Mosinger said. "This is because most safety tests were done using animals, which have T1R3 receptors that are insensitive to these compounds."

Ultimately, he said, "given the number of compounds used in agriculture, medicine and the food industry that may affect human T1R3 and related receptors, more work is needed to identify the health-related effects of exposure to these compounds."

More information

Learn more about the sense of taste in this presentation for kids by the University of Washington.



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