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Vitamin C: Tips For Increasing Your Intake
A new RDA?

According to a recent issue of the Journal of the American Medical Association (JAMA), the National Institutes of Health is taking another look at the Recommended Daily Allowance (RDA) for vitamin C. The current RDA for vitamin C is 60 milligrams per day—about the amount you get from one orange. Due to recent findings on the potential health benefits of this wonder vitamin, the NIH is now considering boosting the RDA to somewhere between 100 and 200 milligrams per day, two to three times the current recommendation.
Why all the hype?

Vitamin C has long been known for its value as an antioxidant. Antioxidants are natural compounds found in many of the foods we eat. The most well known antioxidants are vitamin C, selenium, beta carotene and vitamin E. Antioxidants work by inhibiting toxic substances in the body (also known as "free radicals") which may lead to the development of cancers, heart disease and the aging process. There has been a strong correlation between diets high in fruits and vegetables (which are rich in antioxidants) and reduced risk of chronic diseases. Vitamin C may account for much of this protection. However, we are also finding numerous other compounds within fruits and vegetables, collectively called "phytochemicals", that may also play a preventative role. Phytochemicals are defined simply as chemicals found in plants. They occur naturally in fruits, vegetables, grains, nuts and seeds. These substances, many of which also have an antioxidant effect, may protect our bodies from cellular damage that can lead to cancer and other chronic diseases.

Due to the strong correlation between diets abundant in fruits and vegetables and disease prevention, The National Cancer Institute launched the "5-A-Day" program. The basis of this campaign promotes the intake of a minimum of five fruits and vegetables daily as a good defense against cancer and other diseases. A specific recommendation of this program is to include vitamin C rich fruits and vegetables in the diet each day since vitamin C is a particularly well-researched antioxidant. The mainstay of the program, however, is that by eating five servings of produce daily we can easily take in not just a good dose of vitamin C, but the minimum amount of protective plant chemicals shown to be effective in reducing risk of chronic diseases. Remember, five is the minimum amount. In the case of fruits and veggies it's definitely a situation where more is better!

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Arzerra Approved for Chronic Lymphocytic Leukemia

TUESDAY, Oct. 27 (HealthDay News) -- Arzerra (ofatumumab) has been approved by the U.S. Food and Drug Administration to treat chronic lymphocytic leukemia (CLL), a cancer of the blood and bone marrow.

The drug, produced by London-based GlaxoSmithKline, is approved when other types of chemotherapy no longer control the disease, the FDA said in a news release.

CLL, a slowly progressing form of leukemia, mostly affects people aged 50 and older. Some 16,000 people annually are diagnosed with the disease, and about 4,400 die, the agency said.

Arzerra binds to white blood cells known as B cells, making it easier for the body's immune system to fight cancerous B cells. The drug was approved under an accelerated process granted to drugs that satisfy unmet medical needs, the FDA said. Ongoing studies will establish whether combining Arzerra with standard forms of chemotherapy delays progression of CLL.

Common side effects recorded during clinical testing of Arzerra included an increased risk of progressive multifocal leukoencephalopathy (PML), an often-fatal brain infection. Also, people with a history of hepatitis should be carefully monitored while taking the drug.

Other side effects may include a decrease in blood cell counts, pneumonia, fever, cough, diarrhea, fatigue and shortness of breath, the FDA said.

More information

The FDA has more about this drug's approval history.



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