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Contributing factors to the development of androgen deficiency include:

Medications, especially those used to treat depression or mental disorders

Alcoholism

Chemotherapy or radiation treatment for cancer that targets or harms the testicles

Chronic illness

Dysfunction of the pituitary gland (a gland in the brain that produces substances that regulate hormone production from the brain to the testis)

Hemochromatosis (too much iron in the blood)

Hypogonadism (when the testis is not able to produce high enough levels of testosterone, aka androgen deficiency, or sperm, aka spermatogenesis)

Inflammatory diseases, such as sarcoidosis (a condition that causes injury to or infection of the testicles)

Illnesses, such as AIDS, that compromise the immune system

Excessive stress, which taxes the adrenal system.

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