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Treatments

Antiepileptic drugs (AEDs) can prevent seizure activity by altering neurotransmitter activity in nerve cells, but cannot correct the underlying condition. Approximately 70% of patients successfully control seizures with medication. Nearly 50% of those require two drugs to be seizure free. Because medications interact, the drug regimen must be carefully designed to maximize the effectiveness and to avoid serious complications and side effects.

Treatment with a single drug (monotherapy) is the goal. Seizure management is complicated when patients are given more than one drug. The patient may experience drug interactions, increased side effects, and other adverse reactions.

Compliance is essential. To control seizures, a constant level of medication must be maintained in the body. Antiepileptic drugs should not be discontinued abruptly because of the risk for triggering life-threatening status epilepticus.

Although, antiepileptic drugs may cause abnormal embryo development (i.e., have teratogenetic potential), most women with epilepsy require treatment to prevent seizures during pregnancy. To control seizures and minimize risk to the fetus, women should educate themselves about medication and pregnancy prior to conception.

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