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A very low-calorie diet (VLCD) is a doctor-supervised diet that typically uses commercially prepared formulas to promote rapid weight loss in patients who are obese. These formulas, usually liquid shakes or bars, replace all food intake for several weeks or months. VLCD formulas need to contain appropriate levels of vitamins and micronutrients to ensure that patients meet their nutritional requirements. Some physicians also prescribe VLCDs made up almost entirely of lean protein foods, such as fish and chicken. People on a VLCD consume about 800 calories per day or less.

VLCD formulas are not the same as the meal replacements you can find at grocery stores or pharmacies, which are meant to substitute for one or two meals a day. Over-the-counter meal replacements such as bars, entrees, or shakes, should account for only part of one’s daily calories.

When used under proper medical supervision, VLCDs may produce significant short-term weight loss in patients who are moderately to extremely obese. VLCDs should be part of comprehensive weight-loss treatment programs that include behavioral therapy, nutrition counseling, physical activity, and/or drug treatment.

Studies show that the long-term results of VLCDs vary widely, but weight regain is common. Combining a VLCD with behavior therapy, physical activity, and active follow-up treatment may help increase weight loss and prevent weight regain.

In addition, VLCDs may be no more effective than less severe dietary restrictions in the long run. Studies have shown that following a diet of approximately 800 to 1,000 calories produces weight loss similar to that seen with VLCDs. This is probably due to participants’ better compliance with a less restrictive diet.

For most people who are obese, their condition is long-term and requires a lifetime of attention even after formal weight-loss treatment ends. Therefore, health care providers should encourage patients who are obese to commit to permanent changes of healthier eating, regular physical activity, and an improved outlook about food

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