High Blood Pressure Information
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The diagnosis of high blood pressure (hypertension) is defined as a blood pressure greater than 140/90 on two or more occasions.
Keeping a log of your blood pressures to periodically review with you physician can help to assure optimal control.
Lifestyle measures such as a low salt (low sodium) diet, weight reduction, smoking cessation and a regular exercise program can be extremely effective strategies to help control high blood pressure.
Medications are often prescribed to help patients achieve their desired blood pressure goals.
Bleeding Alert Sounded for Stroke Drugs
MONDAY, March 8 (HealthDay News) -- People treated with the clot-dissolving drug tPA for a stroke caused by a blocked brain artery are significantly more likely to have excess bleeding if they have been taking the anti-clotting drug Coumadin, even though a test shows no great danger of bleeding, new research indicates.
"In our small sample, there was a 10-fold increased risk among those taking Coumadin [warfarin]," said study author Dr. Shyam Prabhakaran, an assistant professor of neurological sciences and head of the stroke program at Rush University Medical Center in Chicago. "I think we have raised a doubt that hasn't been looked at before and should make us be sure that tPA is safe for these patients before we move forward."
Current guidelines say that tPA, or tissue plasminogen activator, should be used quickly to dissolve a clot that is blocking a brain artery -- within three hours after the first symptoms, as late as four and a half hours in some cases. But they say that the drug should be used only when a measurement called the international normalized ratio, or INR, which measures the tendency of blood to clot, is 1.7 or lower. A higher INR means a greater tendency to bleed.
The study, published online March 8 in Archives of Neurology, reported on the use of tPA in 107 people who had ischemic strokes, those caused by a blocked artery, from 2002 to 2009. Among them, the incidence of excess bleeding in the 13 people who had been taking Coumadin before the stroke was 30.2 percent, compared with 3.2 percent for those who had not been taking the drug.
Prabhakaran was quick to point out the faults in the study. "It is a single-center, retrospective study and not large enough so that it could be affected by sample size," he said. "We need a larger data set from more centers."
That information should be forthcoming now that an alert has been sounded, Prabhakaran said. "Other centers should now start presenting their data bases," he said. "If their data indicate it is safe, the guidelines should not be changed. I think we will find, in the next year or two, other centers will start publishing their findings."
A large number of Americans, most of them elderly, take Coumadin for a variety of reasons, including to prevent problems caused by atrial fibrillation, an abnormal heart rhythm, and to prevent clots from forming on artificial heart valves.
"This is an important study that talks about the risks we are well aware of when we use tPA for ischemic strokes," said Dr. Ralph Sacco, professor and chairman of neurology at the University of Miami Miller School of Medicine. Sacco, president-elect of the American Heart Association and the first neurologist to hold that post, was a member of the group that set the guidelines for tPA use.
"The new updated guidelines that extended use of tPA beyond the three-hour window did exclude all patients taking Coumadin [from being] treated after three hours, regardless of INR level," Sacco said.
He echoed Prabhakaran's list of the new study's shortcomings. "This is a non-randomized study," Sacco said. "All-case studies always raise concerns about some bias."
But attention must be paid, he said. "This raises the alarm level and makes us pause, as we always should, when we consider treating ischemic stroke," Sacco said. "But it should not make us deviate from the guidelines."
More information
Learn more about the use of tPA from the American Heart Association.
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