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Muscle Weakness Linked to Alzheimer's Risk in Seniors

November 10, 2009
Reason for association unknown, but stroke is one possibility, researchers say. Elderly people with weak muscles may be at increased risk for Alzheimer's disease, according to a new study.

Researchers at Rush University Medical Center in Chicago followed 970 older adults (average age 80) who didn't have dementia at the start of the study. The participants underwent a number of evaluations, including tests of cognitive function and muscle strength.

Early Use of NSAIDs Might Prevent Alzheimer's

November 10, 2009
Study in mice finds anti-inflammatories don't help those with existing disease. Taking nonsteroidal anti-inflammatory drugs (NSAIDs) from a young age might prevent early signs of Alzheimer's disease, according to the results of a new study in mice.

Recent research suggests that the appearance of neuronal cell cycle events (CCEs) occurs early in the development of Alzheimer's. In the new study, U.

High Blood Pressure Likely in Alzheimer's Offspring

November 02, 2009
And hypertension could contribute to developing the brain disease, study finds. Middle-aged adults whose parents have Alzheimer's disease are at increased risk for high blood pressure, evidence of arterial disease and markers of inflammation .

Does Diabetes Slow Alzheimer's?

October 26, 2009
French study suggesting delayed progression gets guarded response from U.S. experts. A French study finding that people with Alzheimer's disease and diabetes have less memory loss than those without diabetes should be regarded with caution, American experts say.

"It's not clear from this study and others what the relationship is," said William Thies, chief medical and scientific officer of the Alzheimer's Association.

What is clear, Thies said, is that having diabetes increases the risk of developing Alzheimer's disease .

Families Need to Know When Dementia Becomes Terminal

October 14, 2009
Too often, onerous and futile medical interventions are ordered for these end-stage patients, researchers say. Many people see end-stage dementia as affecting only the mind, but a new study shows that the disease's effects are far-reaching and eventually fatal.

The misconception by family members that end-stage dementia is not a terminal condition can have negative consequences for the patient, the researchers say. That's because concerned loved ones often order aggressive, sometimes burdensome interventions such as feeding tubes that will not improve patient outcomes.

Drop in Certain Visual Skills May Precede Alzheimer's

October 12, 2009
Decline in spatial understanding can occur 3 years before diagnosis, study finds. The ability to perceive relationships between objects (visuospatial skills) may decline years before a person is diagnosed with Alzheimer's disease, a new study suggests.

It included 444 people who were dementia-free when they were enrolled in the study and underwent tests on a number of cognitive abilities, including visuospatial skills. The assessments were repeated at least once before the end of the study.

Hairstylists Often Privy to Older Clients' Health Issues

October 04, 2009
Some see chance to steer them towards local elder services, report suggests. Hairstylists can do more than make their clients look good, they may also be helpful in getting some elderly people the health-care services they need, an Ohio State University study suggests.

A survey of 40 stylists in the Columbus, Ohio-area found that most develop long-term relationships with their older clients, and these seniors tend to talk freely about their troubles .

Uncertainty Surrounds Testing for Alzheimer's

October 02, 2009
Early diagnosis is helpful, but no sure-fire test exists, experts say. The earlier a diagnosis of Alzheimer's disease is made, the earlier treatment can begin. On that, experts agree.

With a growing array of tests available to predict your odds of developing the degenerative brain disorder .

Dementia Risk Higher for NFL Players

September 30, 2009
Ex-players aged 30 to 49 are 19 times more likely to have memory problems, survey found. Former professional football players suffer from Alzheimer's disease or other memory-related conditions at rates far higher than the general population, a new study commissioned by the National Football League shows.

And retired players between the ages of 30 and 49 are 19 times more likely to struggle with memory problems than similarly aged men who never played professional football, the study found.

The findings could have implications that reach far beyond the National Football League, which has said in the past that there's no reliable research to establish the proof of cognitive problems among former players.

Sleep Deprivation Might Lead to Alzheimer's

September 24, 2009
Research in mice suggests that suspect plaques build up during waking hours. If you're middle-aged, you might want to try a little harder to get a good night's sleep, now that new research suggests the right amount of slumber might keep Alzheimer's disease at bay.

The research was conducted in mice and is preliminary, and it may not apply to humans. Still, the possible link between sleep deprivation and Alzheimer's raises the prospect of possible treatments that target related pathways in the brain, explained study author Dr.

Preventing Second Stroke May Stave Off Dementia

September 24, 2009
Not all agree, though, that biggest risk factor is the brain attack itself. The way to reduce the chances of developing dementia such as Alzheimer's disease after a stroke is to prevent a second stroke by concentrating on all the known stroke risk factors, a new British study suggests.

Two major findings emerged from an analysis of 30 previous studies that involved more than 7,500 people who had suffered a stroke, said Dr. Sarah Pendlebury, a senior clinical fellow at the Stroke Prevention Research Unit of John Radcliffe Hospital in Oxford and lead author of a report published online Sept.

Mishandling Money May Foreshadow Alzheimer's

September 21, 2009
Trouble writing checks, paying bills preceded dementia, study found Money management difficulties may be a sign that people with mild memory problems will soon develop Alzheimer's disease, a new study suggests.

It included 87 older people with mild cognitive impairment, and 76 others with no memory problems. All the participants took a money management test at the start of the study and again one year later.

Alzheimer's Soars, Global Focus Needed

Study

September 21, 2009
By 2050, 115 million people may suffer from dementia The prevalence of Alzheimer's disease is accelerating at a rapid pace, and by next year 35.6 million people around the world will suffer from dementia .

Older Brains May Not Be So Small After All

September 21, 2009
Decrease in gray matter isn't a given, researchers find. Scientists have assumed that people's brains shrink as they age, but researchers now suspect that's not the case.

A study in the September issue of Neuropsychology examines long-term Dutch research into aging brains, which used neurological tests and MRI scans to measure parts of the brain.

The researchers looked at data from 1994 to 2005 for two groups: 35 people who were cognitively healthy and 30 people who did not have dementia but experienced cognitive decline during the time period.

Trouble With Daily Activities Could Point to Alzheimer's Risk

September 17, 2009
Unusual pattern seems to predict quicker dementia onset, study finds. Problems carrying out daily chores or enjoying hobbies could predict which people with "mild cognitive impairment" will progress more quickly to Alzheimer's dementia, U.S. researchers report.

Alzheimer's Gene Affects Brains of Young Adults

September 11, 2009
Finding might help predict who's susceptible to the disease, study says. A gene variant linked to a higher risk of Alzheimer's disease seems to affect the brain when people are young, much earlier than previously thought, new research suggests.

The brains of people in their mid-20s who had the gene variant known as APOE4 .

Cancer Drug May Fight Alzheimer's

September 08, 2009
Short-term memories maintained in mice given HDAC inhibitors, study finds New research suggests that a cancer drug might be able to restore day-to-day memory in patients with Alzheimer's disease.

The disease, the most common form of dementia among the elderly, is expected to afflict 120 million people worldwide by 2050. Often the first sign is loss of short-term memory.

Even Mild Infections Hasten Decline With Alzheimer's

September 08, 2009
They speed memory loss as much as 10-fold, researchers find. For people with Alzheimer's disease, even a minor infection can double the rate of memory loss, British researchers report.

In this new study, researchers found that Alzheimer's patients who had respiratory, gastrointestinal or other infections .

Trio of Gene Variants Discovered That May Raise Alzheimer's Risk

September 06, 2009
Study suggests they're implicated in clearance of amyloid plaque from brain. Two international teams of scientists have uncovered three gene variants that up the risk for Alzheimer's disease, the most common form of dementia among the elderly and the seventh-leading cause of death in the United States.

Teams led by Dr. Philippe Amouyel of the Institut Pasteur de Lille in France, and Julie Williams, a professor of psychological medicine at Cardiff University School of Medicine in Wales, zeroed in on defects in the CLU, CR1 and PICALM genes, and also found another 13 gene variants that are solid candidates for further investigation, according to findings that appear in the Sept.

Health Tip

Keep Seniors Safe at Home

September 01, 2009
Suggestions for people with dementia If a loved one with dementia is living at home with supervision, it's still important to eliminate potential dangers.

The Alzheimer's Association offers these suggestions:


Make sure the house is equipped with working fire extinguishers, carbon monoxide detectors and smoke detectors.
Keep all hazardous areas locked or blocked, such as the garage or stairs.

As Waistlines Widen, Brains Shrink

August 26, 2009
The obese and overweight have less neurological tissue, study finds. For every excess pound piled on the body, the brain gets a little bit smaller.

That's the message from new research that found that elderly individuals who were obese or overweight had significantly less brain tissue than individuals of normal weight.

"The brains of obese people looked 16 years older than their healthy counterparts while [those of] overweight people looked 8 years older," said UCLA neuroscientist Paul Thompson, senior author of a study published online in Human Brain Mapping.

MRI Might Find Early Alzheimer's

August 24, 2009
Detection could help slow down the disease, study says. The brains of people in the very early stages of Alzheimer's disease might become hyperactive to compensate for disease-related deterioration, a new study suggests.

Researchers from the Cleveland Clinic tested 69 mentally healthy adults, two-thirds of whom were at risk for Alzheimer's disease because of family history or genetic markers. Functional MRI was used to monitor the participants' brains as they were asked if they recognized the names of famous celebrities and unfamiliar people.

Mediterranean Diet Plus Exercise Lowers Alzheimer's Risk

August 11, 2009
Older adults who ate healthy and remained active were protected, study finds. Eating a Mediterranean diet, which emphasizes fruits, vegetables, legumes and healthy fats, and increasing physical activity levels can reduce the risk of developing Alzheimer's disease, a new study shows.

The latest research, published in the Aug. 12 issue of the Journal of the American Medical Association, is more evidence that healthy living can help ward off cognitive decline.

Mental Activity Seems to Keep the Brain Vital

August 09, 2009
Rapid memory loss may be delayed by stimulating activities, study finds. Older adults might want to remember to exercise their brains regularly.

Brain-stimulating activity, according to a new study, can delay the rapid loss of memory that precedes dementia.

For five years, researchers followed 488 adults, aged 75 to 85, who did not have dementia at the start of the study.

Special Eye Drops May Reverse Glaucoma Damage

August 04, 2009
More testing still needed, but nerve growth factor proved effective in study. A new type of eye drop appears to protect retinal and optic nerve cells .

Midlife Heart Risk Factors Linked to Later Dementia

August 04, 2009
High cholesterol and blood pressure, diabetes and smoking increase Alzheimer's risk decades later, new research shows. The things that are bad for your heart in the middle years of life .

Protein Clumps May Appear Years Before Memory Problems

July 29, 2009
Discovery could help in Alzheimer's prevention efforts, researcher says. Amyloid protein deposits in the brain play a role in disrupting the memory formation process long before a person shows symptoms of the memory impairment of Alzheimer's disease, a new study contends.

Previous research had suggested that clumps of amyloid protein, which damage neurons and are characteristic of Alzheimer's disease, begin appearing many years before Alzheimer's symptoms appear. But the link between the deposits and memory impairment had not been clearly demonstrated in humans.

Cellular Protein Yields Clues to Diabetes, Alzheimer's

July 22, 2009
Animal tests suggest humanin could have therapeutic benefits. New information about a cellular protein might help in efforts to develop drug treatments for diabetes and Alzheimer's disease, researchers say.

In tests on rats, they found that humanin, which may prevent nerve cells from dying, also helps improve insulin action and lower blood glucose levels.

"This new role of humanin in glucose metabolism, in addition to its role in Alzheimer's disease, is very intriguing since scientists have long proposed a link between type 2 diabetes and Alzheimer's disease," Dr.

Biomarkers May Predict Alzheimer's

July 21, 2009
Proteins in spinal fluid may help diagnose disease early, study shows Certain proteins found in cerebrospinal fluid may accurately identify the people with mild cognitive impairment who are most likely to develop Alzheimer's disease, a new study finds.

Changes in the chemistry of cerebrospinal fluid have been identified as early signs of Alzheimer's disease. If and when treatments are available for Alzheimer's, diagnosing the disease early may help prevent it from developing, experts say.

New Alzheimer's Treatment Could Be on the Horizon

July 20, 2009
Potential of immune system treatment is 'exciting,' expert says. A treatment already used to bolster the immune systems of people with leukemia and other serious diseases might also help ward off Alzheimer's disease, new research suggests.

Researchers looked at the association between the use of intravenous immunoglobulin (IVIg) and the occurrence of Alzheimer's. "IVIg has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer's disease by targeting beta-amyloid, or plaques, in the brain," said Dr.

Signs of Alzheimer's Seen Earlier Than Thought

July 15, 2009
Second study found that individuals who were informed about their risk weren't devastated. Giving scientists insight into the origins of a devastating illness, new research suggests that people with a genetic propensity to develop Alzheimer's disease start experiencing memory loss as early as their 50s.

Unfortunately, scientists don't know of any way to prevent Alzheimer's. But an accompanying study finds that nearly everyone told of their high genetic risk of the disease was glad that they had been informed.

New Treatments for Alzheimer's on the Horizon

July 15, 2009
Studies show Dimebon could improve cognition, vaccine might fight 'tangles' of disease. New interventions show promise against two different types of brain abnormalities, both of which are implicated in the development and progression of Alzheimer's disease.

A drug called Dimebon seems to improve cognitive function in both mice and humans but, new research reveals, it actually increases brain levels of beta amyloid, a protein long thought to be a leading culprit in the development of Alzheimer's disease.

Meanwhile, a vaccine has had some effect in reducing the number of tau protein tangles that are also associated with Alzheimer's.

Key Protein Might Shield Brain Cells

July 15, 2009
Discovery could spur new drugs for neurodegenerative diseases, researchers say. A protein that can protect brain cells from dying has been identified by U.S. researchers, who said their finding may lead to new drugs to protect against Alzheimer's disease and other neurodegenerative conditions.

Healthy Diet, Exercise Keeps Mind Sharp As You Age

July 14, 2009
New research finds eating healthy, moderate activity are protective. Eat right, exercise and hope that your genes don't predispose you to dementia.

That's the recipe for preserving cognitive function as you age, according to four new studies that were presented this week at the Alzheimer's Association annual meeting, in Vienna.

The findings echo other research suggesting that clean living can safeguard mental sharpness.

Dementia Increasing Among the 'Oldest Old'

July 13, 2009
Those over 90 have highest rate, new study finds. Scientists tend to think that dementia and Alzheimer's disease taper off in the oldest, but a new study finds that people over 90 have the highest rates.

According to previous epidemiological research, the rate of dementia begins to level off and even decline among people aged 90 and older. But this new study found that the rate of dementia increases with age.

Moderate Drinking Might Guard Against Alzheimer's

July 13, 2009
But only among those who are not cognitively impaired, study finds. Older adults with no history of dementia could cut their odds of Alzheimer's and other cognitive decline by regular moderate drinking, new research suggests.

Defining "moderate" as having one to two drinks a day, the study authors observed that drinking in this range was associated with a nearly 40 percent drop in dementia risk, compared with non-drinkers.

However, those with a history of even moderate brain health issues did not appear to benefit from any amount of alcohol consumption, and appeared to face a significantly greater risk for dementia in the face of a heavy drinking habit.

Doctors' Attitudes Play Part in Early Alzheimer's Diagnosis

July 13, 2009
Positive attitude critical to spotting disease, study finds..

Gene May Help Predict Timing of Alzheimer's Onset

July 13, 2009
Discovery of TOMM40 adds to understanding of disease development. A gene that may offer a highly accurate prediction of the risk of developing Alzheimer's disease and the age at which people will begin to show symptoms has been identified by U.S. researchers.

Omega-3 Fatty Acid Falls Short in Alzheimer's Trials

July 13, 2009
No significant benefits seen with DHA, either in terms of prevention or treatment. Two trials that looked at whether the omega-3 fatty acid DHA might treat or prevent Alzheimer's disease have produced mixed results.

The studies were done because of "a long history of epidemiological studies that related fish consumption to cognitive function," explained Bill Thies, chief medical and scientific officer of the Alzheimer's Association. Fish is rich in DHA, but the research scheduled to be presented Sunday at the association's annual meeting in Vienna, Austria, used DHA derived from algae.

Severe COPD Linked to Mental Decline

July 09, 2009
Doctors need to recognize challenges these patients face, researchers say. Severe chronic obstructive pulmonary disease appears linked to lower cognitive function in older adults, making it more difficult for them to remember and perform daily tasks, a new study finds.

Researchers at Mount Sinai School of Medicine in New York City analyzed national data on 4,150 Americans aged 50 and older, including 492 with COPD. Of those, 153 had severe COPD.

Greater Language Skills in 20s May Guard Against Alzheimer's

July 08, 2009
Small study found women who wrote more articulate essays were protected from symptoms. Women with greater language abilities in early adulthood were less likely to have Alzheimer's disease later in life, even when autopsies revealed the clear brain changes that are hallmarks of the disease.

Also, the brains of women without symptoms of Alzheimer's housed bigger neurons, according to a study appearing in the July 9 online edition of Neurology.

"We noticed that the neurons in this group of people are larger and we also know that the same group of people we call asymptomatic also had higher language skills during their 20s," said study author Dr.

More Evidence That Caffeine Can Jolt Memory

July 06, 2009
High doses may protect against Alzheimer's symptoms, study in mice suggests. The growing evidence that caffeine consumption may help treat or prevent Alzheimer's disease has received an extra boost from two new studies.

Florida researchers report that a daily dose of 500 milligrams of caffeine .

Living Alone Increases Odds of Developing Dementia

July 02, 2009
Losing a partner through divorce or death in middle age may triple the risk, study shows. Middle-aged adults who live alone are twice as likely to develop dementia or Alzheimer's disease later in life compared to those who are married or live with a partner. And the risk is three times higher among those who are divorced or widowed, according to a new study by Swedish and Finnish researchers.

The study included 2,000 men and women in Finland who were initially surveyed when they were about 50 years old and again 21 years later.

Hormones May Affect Neurological Disease Risk

June 30, 2009
Women are more vulnerable during certain stages of life, study finds. Fluctuating hormone levels may explain trends in the timing of women's susceptibility to neurological diseases such as Parkinson's, schizophrenia, Alzheimer's, Tourette's and attention-deficit/hyperactivity disorder, new research suggests.

Significant estrogen level changes occur at various stages of women's lives, including adolescence and menopause, and as a result of menstrual cycles. The onset or exacerbation of neurological diseases are most likely to occur at these times, said researchers at the University of Texas Medical Branch.

Statins Might Stave Off Alzheimer's

June 30, 2009
In animal study, drug blocks cell death characteristic of the disease. Treatment with a cholesterol-lowering drug might protect against Alzheimer's disease, new research suggests.

Scientists have long known that nerve cells in people with Alzheimer's die prematurely because they are strongly overstimulated, a process called excitotoxicity.

Theorizing that the cholesterol drug lovastatin might ward off cell death, researchers at the University of Groningen, The Netherlands, conducted animal experiments in which they administered lovastatin (Altoprev, Mevacor) to overstimulated nerve cells.

Clues to Alzheimer's Spotted Earlier in Disease

June 24, 2009
Researchers found biomarkers in patients with only mild memory problems. Biomarkers for Alzheimer's disease can be detected in the cerebrospinal fluid in the very early stages of the disease, a Swedish study suggests.

University of Gothenburg researchers analyzed cerebrospinal fluid (CSF) samples from 168 patients and found the typical pattern of biomarkers known as the "CSF AD profile" present in patients with mild memory problems, which is earlier than the illness could be detected by current tests.

"The earlier we can catch Alzheimer's disease, the more we can do for the patient," researcher Kaj Blennow said in a university news release.

Stay Upbeat, Active to Keep the Mind Young

June 24, 2009
Though the brain may slow with aging, good habits can help you cope, experts say. To stave off the mental decline associated with old age, engage in intellectually challenging activities, maintain a positive outlook and keep up your social life.

Those are the findings of what researchers say is the largest-ever review of studies on aging and the brain.

The review, which spanned three decades and covered more than 400 studies, found that remaining physically, mentally and socially active has a substantial impact on whether older adults experience declines in memory and cognition, which includes the ability to learn and solve problems.

Drug May Stem Slide Into Alzheimer's for Some

June 15, 2009
Aricept did not affect others with mild memory loss, study finds. Depression might increase the chance of developing Alzheimer's disease among those already experiencing memory problems, a new study says.

But the drug donepezil (Aricept), commonly prescribed for people with Alzheimer's, could slow the depressed person's slide into the disease, the study also found.

The findings are reported in the June 16 issue of Neurology.

Questionnaire May Help Spot Early Dementia

June 10, 2009
Experts caution that do-it-yourself test still needs doctors' interpretation. A new test that evaluates cognitive ability .

Alzheimer's and Even Mild Dementia Hasten Death

June 09, 2009
But researchers determine that race has no bearing on life expectancy in such cases. Older adults with mild cognitive impairment or Alzheimer's disease have a shorter life span than other older adults, but the risk of death is no greater for whites or blacks, a new study says.

The study, conducted by researchers at Rush University Medical Center in Chicago, contradicts earlier information indicating blacks with Alzheimer's live longer than whites with the disease.

Researchers examined 1,715 older adults with an average age of 80 from four adjacent neighborhoods in Chicago.

Some OTC Sleep, Cold Meds Could Harm Aging Brain

June 05, 2009
Drugs with benadryl as ingredient linked to slowed thinking, delirium in elderly, report finds.Older people taking common over-the-counter drugs for pain, cold symptoms or help with sleep may increase their risk for cognitive impairment, including delirium, University of Indiana researchers report.

These drugs include Benadryl, Dramamine, Excedrin PM, Nytol, Sominex, Tylenol PM and Unisom.

All of these over-the-counter (OTC) drugs contain benadryl (diphenhydramine), a molecule that blocks the neurotransmitter acetylcholine.

Video May Help People Make End-of-Life Choices

May 29, 2009
Seeing what life might one day be like can be powerful, study says. Seeing a video of someone with advanced dementia can help people facing the same fate make more informed decisions about the type of care they want at the end of their life, a new study suggests.

"Medicine is involving patients in a shared decision-making process about their medical care at the end of life," said the study's lead researcher, Dr. Angelo Volandes, from the Department of Medicine at Massachusetts General Hospital in Boston.

Plaques, Tangles in Brain Don't Always Lead to Alzheimer's

May 27, 2009
Study raises questions about possible link. New British research provides more evidence that the bits of gunk in the brain known as plaques and tangles don't necessarily lead to Alzheimer's disease, as many experts have long believed.

In fact, the study found that many people over the age of 75 had signs of significant clogging in their brains but still managed to avoid senility.

The findings don't have immediate ramifications for the treatment of Alzheimer's disease, which remains incurable and only somewhat treatable.

Why Chimps, Monkeys Don't Develop Alzheimer's

May 25, 2009
Study shows the plaques in non-human primates differ from those in humans. Scientists have long noticed a curious phenomenon among primates: Humans get the devastating neurological disorder known as Alzheimer's disease, but their closest evolutionary cousins don't.

Even more inexplicable is the fact that chimpanzee and other non-human primate brains do get clogged with the same protein plaques that are believed by many to cause the disease in humans.

The answer to this puzzle could yield valuable insight into how Alzheimer's develops and progresses, and now researchers report they may have a clue.

Rapid Weight Loss in Seniors Signals Higher Dementia Risk

May 19, 2009
Researcher notes it may be less a cause of cognitive decline than a sign of it. Losing weight rapidly late in life seems to signal a greater risk of experiencing some form of dementia, new research suggests.

For older adults, "basically, we saw that if you are thinner or are losing weight at a faster rate, then you are at a higher risk of developing dementia," said study author Tiffany F. Hughes, a postdoctoral fellow in the department of psychiatry at the University of Pittsburgh School of Medicine.

Irregular Heartbeat Tied to Alzheimer's Disease

May 17, 2009
Atrial fibrillation raised risk for dementia, study shows. The abnormal heartbeat called atrial fibrillation is associated with later development of Alzheimer's disease, a large-scale study finds.

There are three possible explanations for the relationship, each of which could lead to early treatment aimed at preventing the dementia, said study author Dr. T.

15-Point Test Gauges Alzheimer's Risk

May 13, 2009
In older volunteeers, the screening tool predicted start of dementia. Researchers have developed a 15-point test that can identify the risk for developing Alzheimer's disease in older people.

But the tool, which involves both simple questions as well as complex physiological testing, may not be practical for clinical use.

"Some of the points on there are fairly easy, such as age and mental status exams.

Eye Disease, Cognitive Decline Linked in Study

May 12, 2009
Research indicates that dementia and age-related macular degeneration may have a common cause. Seniors who perform poorly on tests of language, memory and concentration are more likely to be suffering from the early stages of age-related macular degeneration, a major cause of vision loss, a new study suggests.

The finding stems from a look at the association between cognitive function decline and the onset of age-related macular degeneration (AMD) among approximately 2,000 Australian seniors between the ages of 69 and 97.

"We found that those who have memory impairment were more likely to have early stages of macular degeneration independent of the effects of age, education and vascular risk factors," said study co-author Dr.

Biomarkers May Help Measure Rate of Decline in Dementia

May 12, 2009
Cerebrospinal fluid could be key in improving Alzheimer's research. Checking levels of certain biomarkers in cerebrospinal fluid may help predict the rate of cognitive decline in people with very mild dementia, and this information could be used to improve the effectiveness of clinical trials, say U.S. researchers.

Science Zeroes In on New Alzheimer's Drug Target

May 06, 2009
Ridding mice of a key DNA-linked enzyme gave them back their memory, researchers say. Drugs that control the "wrapping" of certain DNA have brought back learning and memory to mice stricken with an Alzheimer's-like disease .

Delirium Episodes Could Hasten Alzheimer's-Linked Decline

May 06, 2009
Extreme confusion is often tied to surgery, anesthesia, experts note. The delirium sometimes experienced by people with Alzheimer's who are hospitalized might accelerate their cognitive decline, a new study shows.

Researchers found that people with Alzheimer's who had an episode of delirium while in the hospital had a rate of cognitive decline that was three times faster than that of those who didn't experience delirium.

"From a clinical standpoint, this study suggests that over 12 months, patients with AD [Alzheimer's disease] who become delirious experience the equivalent of an 18-month decline compared to those who do not experience delirium," the study's authors wrote.

U.S. Mental Health Spending Rises, But Many Still Left Out

May 05, 2009
Access to care improves, studies find, but treatment quality lags for elderly, vets. Mental health spending in the United States increased 65 percent in the past decade, and many more Americans are using mental health services, but there's still a big difference between access to care and quality of mental health care received, new research shows.

In a special edition of the May/June issue of Health Affairs focusing on mental health care in the United States, one study found that about half of Americans suffering from mental illness in a given year don't receive treatment, and another 25 percent receive treatment that's not consistent with evidence-based guidelines.

Some patients may receive inappropriate treatments, simply because doctors lack the evidence to make an informed decision about appropriate care, noted Philip Wang, acting deputy director of the National Institute of Mental Health, and colleagues.

Early Alzheimer's Hinders Brain's Effort to Sort Information

May 04, 2009
Finding may encourage docs to 'train' patients to recall important facts. Difficulty distinguishing between important and less important information begins in the earliest stages of Alzheimer's disease, U.S. researchers report.

Drink Away Dementia?

May 01, 2009
Study shows one to two drinks daily may lower risk of cognitive decline in older adults. Moderate drinking can lower the risk of dementia in older people, new research shows.

"Amongst cognitively normal adults, one to two alcoholic drinks a day is associated with a 37 percent decreased risk of dementia over six years," said senior study author Dr. Kaycee Sink, an assistant professor of medicine in geriatrics at the Wake Forest University School of Medicine, in Winston-Salem, N.

Painkillers May Not Protect Against Dementia

April 22, 2009
Contrary to prior research, study finds older people taking NSAIDs more likely to suffer decline. Research has suggested that older people who want to avoid Alzheimer's disease might want to take daily doses of painkillers such as ibuprofen and naproxen, but a new study suggests that might not be the best idea.

"If people are thinking, 'Should I take these to prevent dementia?', the answer based on our study would be no," said study author Dr. Eric B.

Simple Steps to Maintaining Memory

April 19, 2009
Tipsheet offers strategies to help older adults stay sharp. Conquering the world (at least in a video game) is just one of many ways that older adults can fight age-related changes in memory.

In this case, a study found that older adults improved their memory and certain other mental abilities by playing a video game in which they had to use planning and strategy to take over the world, according to the American Geriatric Society's Foundation for Health in Aging.

Other researchers have found that simply expecting to remember things can help older people recall and recollect and that including carbohydrates in the diet and avoiding multi-tasking can also improve memory.

Newer Antipsychotics May Boost Weight in Alzheimer's Patients

April 15, 2009
Drugs such as olanzapine, quetiapine may also lower 'good' cholesterol, researchers say. Alzheimer's Disease (CATIE-AD) study, funded by the U.S. National Institute of Mental Health.

Severe Low Blood Sugar Ups Older Diabetics' Dementia Risk

April 14, 2009
Study finds being hospitalized for hypoglycemia linked to mental decline. Older individuals with type 2 diabetes who have been hospitalized with severe low blood sugar levels seem to have a greater risk of developing dementia, new research suggests.

It's not yet clear whether less severe episodes of low blood sugar, which are more common, are also linked with an increased dementia risk, according to a study in the April 15 issue of the Journal of the American Medical Association, a themed issue on diabetes.

"Hypoglycemic episodes that were severe enough to require hospitalization or an emergency-room visit were associated with a greater risk of dementia, particularly for patients who had multiple episodes.

Brain Cells Give New Clues to Alzheimer's

April 02, 2009
Protein plaques disperse a free radical that can damage neurons, scientists say. By uncovering a mechanism that causes damage to brain synapses during Alzheimer's disease, researchers might have found a key to reducing or preventing nerve degeneration for these patients.

According to a report in the April 3 issue of Science, researchers at the U.S.

Protein-Folding Problem May Help Spur Alzheimer's

April 01, 2009
Finding could lead to new target for disease therapy, researchers say. A dysfunction in protein folding contributes to nerve cell death in Alzheimer's disease, a finding that could help lead to new treatments, Dutch researchers report.

The presence of tangles of misfolded proteins is believed to contribute to Alzheimer's disease, the experts explained. A process known as the "unfolded protein response" typically protects cells from the toxic effects of accumulated misfolded proteins.

With Alzheimer's, Health-Care Costs Could Triple

March 24, 2009
Experts urge greater investment in research to stem 'crippling' expenses. In a new report, the Alzheimer's Association estimates that Alzheimer's disease and dementia triple the health-care costs for afflicted seniors.

In addition, people who live in nursing homes or assisted living facilities pay an average of $16,689 in out-of-pocket costs each year, researchers found. The association also estimates that nearly 10 million unpaid caregivers of people with Alzheimer's disease spent 8.

Too Much Red Meat May Shorten Life Span

March 23, 2009
Major study finds an effect, but critics say meat offers important nutrients. Diets high in red meat and in processed meat shorten life span not just from cancer and heart disease but from Alzheimer's, stomach ulcers and an array of other conditions as well, a U.S. National Cancer Institute study has found.

Alzheimer's Tied to Shrinkage in Brain Area

March 16, 2009
Loss of cells in the hippocampus predicts who'll get the disease, study shows. A loss of cells in the hippocampus area of the brain precedes Alzheimer's disease, a new study finds.

The research included 64 Alzheimer's patients, 44 people with mild cognitive impairment (the stage of memory problems that occurs before Alzheimer's), and 34 people with no memory or thinking problems. The Dutch team used MRI to measure the volume of the entire brain, as well as the hippocampus, in all the participants at the start of the study and again an average of 18 months later in order to calculate the rate of brain shrinkage.

Alzheimer's Drug May Someday Help Head Trauma Victims

March 16, 2009
Finding may prevent long-term harm that often follows brain injury, researcher says. A new class of Alzheimer's disease drugs may prevent long-term damage from traumatic brain injury, suggests a study of mice by Georgetown University Medical Center researchers.

The drugs .

Obesity, Diabetes and Heart Disease May Speed Dementia

March 10, 2009
Expert urges people to modify lifestyle after reports find a connection. Obesity and its common companions .

Alzheimer's Plaques More Complex Than Thought

February 26, 2009
They affect neurons and nervous system cells that support brain function, study finds. The impact of amyloid plaques in the brains of people with Alzheimer's disease may be more complex than believed, U.S. researchers report.

Scientists Spot New Clue to Alzheimer's

February 25, 2009
Normally harmless proteins called prions may play key role, researchers say. Yale University researchers believe they've filled in an important missing link in understanding the development of Alzheimer's disease.

They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.

"It's been a black box.

Why Music Triggers a Walk Down Memory Lane

February 25, 2009
Discovery of brain area responsible for link could lead to Alzheimer's treatment, study says. The memories and emotions that people associate with familiar songs can be traced to the medial prefrontal cortex, a part of the brain where the wiring for memories and thoughts about music appears to be linked, a new study says.

The finding, published Feb. 24 in Cerebral Cortex online, might also explain why people with Alzheimer's disease display strong emotional response to songs.

If Parents Had Alzheimer's, Aging May Come Early

February 19, 2009
Presence of ApoE4 gene in offspring makes a difference, study finds. Middle-age people whose parents had Alzheimer's and who carry the so-called Alzheimer's gene might very well have the memory of someone 15 years older, a new study has found.

This memory decline was not detected in people of middle age whose parents had Alzheimer's but who do not carry the gene, known as ApoE4, according to the study.

About 20 percent to 25 percent of the population have at least one copy of the ApoE4 gene, but not all people with the gene develop Alzheimer's, said study co-author Dr.

Secondhand Smoke Linked to Dementia

February 13, 2009
Exposure may increase risk by 44%, researchers say. People exposed to secondhand smoke may face as much as a 44 percent increased risk of developing dementia, a new study suggests.

While previous research has established a connection between smoking and increased risk for dementia and Alzheimer's disease, this new study is the largest review to date showing a link between secondhand smoke and the threat of dementia, the authors said.

"There is an association between cognitive function, which is often but not necessarily a precursor of dementia, and exposure to passive smoking," said lead researcher Iain Lang, a research fellow in the Public Health and Epidemiology Group at Peninsula Medical School in Exeter, England.

Mediterranean Diet Aids the Aging Brain

Study

February 10, 2009
Eating plan seems to reduce the risk of cognitive impairment, dementia. Chalk up another endorsement for the so-called Mediterranean diet: The eating regimen, which is rich in fruits, vegetables, fish and olive oil, may help the brain stay sharp into old age, a new study suggests.

Following the healthful diet reduced the risk of getting mild cognitive impairment .

Tests Gauge Alzheimer's Patients' Ability to Drive

February 09, 2009
Doctors need a standardized method to make these tough decisions, experts say. The loss of driving privileges can be a blow to a person's independence, including people in the early stages of Alzheimer's disease.

Now, new cognitive tests may help doctors determine whether people with the illness are fit to drive.

University of Iowa researchers studied 40 drivers with early Alzheimer's disease and 115 elderly drivers with no diagnosis of dementia.

Brain Protein May Have Potential Against Alzheimer's

February 08, 2009
Study in animals finds memory improvements and less cell degeneration. A naturally occurring brain protein appears able to slow or stop Alzheimer's disease in recent studies done on animal models.

The brain's entorhinal cortex, which supports memory, normally produces brain-derived neurotrophic factor (BDNF); however, its production appears to decrease when Alzheimer's is present. When researchers injected BDNF in lab animals that either were aged, had entorhinal cortex damage or were genetically altered to have Alzheimer's-like symptoms, they found that the animals had improved memory and cognitive skills and that cell degeneration and death was prevented or reversed.

Education Doesn't Slow Alzheimer's Decline

February 02, 2009
Large, 14-year study finds no effect, contradicting previous research. Education does not slow the rate of cognitive decline among the elderly, new research shows.

The finding contradicts several earlier studies that suggested more education lowered the risk for Alzheimer's disease and dementia.

"Your rate of cognitive decline really doesn't depend on the number of years of schooling you've had," said study author Robert S.

Many Alzheimer's Caregivers Admit to Abusive Behavior

January 23, 2009
Incidents were reported by half of family caretakers surveyed in British study. More than half of family members looking after people with dementia admit they have behaved abusively toward their relative, a new British study finds.

Actual physical abuse was rare, being reported by only three of the 220 caretakers in the study. But the researchers, who published their findings in the Jan.

Moderate Alcohol Consumption May Protect Against Disabilities

January 22, 2009
Study found healthy older adults were better able to carry out daily tasks. Healthy people 50 and older who drink alcohol moderately are less likely to suffer physical disabilities that cause so many seniors to lose their independence, a new study says.

The study authors said their research showed that healthy older adults who were light-to-moderate drinkers had 25 percent lower odds of being unable to carry out daily activities such as walking, dressing, eating, running errands or doing chores.

Conversely, heavy drinkers and abstainers had higher risks of disabilities that would limit such activities.

Decide for Me When I Can't, Most People Say

January 21, 2009
Study finds support for surrogates enrolling loved ones in research studies. Older Americans support having their family members enroll them in disease research studies should they become incapable of making the decision themselves, a new study says.

The findings, based on a University of Michigan study, would prove especially helpful in studying people with Alzheimer's disease, which often impairs decision-making ability, making people unable to give proper consent for scientists to study their condition.

The survey of people age 51 and older found that at least 68 percent believed family surrogates should be able to grant consent for a mentally incapacitated loved one to participate in a research study.

Simple Exercise Keeps Brain at Top of Its Game

January 20, 2009
In older women, being more fit helps cognitive function, study shows. Physical fitness may be as good for the brain as it is for the body in old age, a new study says.

A study of Canadian women older than 65 found that those who took part in regular aerobic activity had cognitive function scores 10 percent higher than their peers who did not exercise. The active women also had lower blood pressure (at rest and during exercise) and better vascular responses in the brain, suggesting that better blood flow aids the ability to think, the study found.

Positive Outlook Cuts Chances of Dementia

January 19, 2009
New research suggests relaxed, outgoing people less likely to get Alzheimer's. Sociable people who don't sweat the small stuff may be more likely to remember the small stuff as they age, suggests new research exploring the link between personality and the incidence of Alzheimer's disease.

"Older people who are active, outgoing and relaxed may be less likely to develop dementia," said study author Hui-Xin Wang, with the Karolinska Institute in Stockholm, Sweden.

The study, published in the Jan.

Memory Loss Tied to Brain's White Matter

January 15, 2009
MIT team says cognition suffers as nervous system network decays with aging. The "white matter" that connects the regions of the brain may have more of a role in memory and cognitive loss than previously believed, a new study says.

By comparing brain scans of groups of healthy young and old adults, Massachusetts Institute of Technology (MIT) neuroscientists discovered a relationship between loss of memory and cognitive performance in older people and the deterioration of the white matter in the parts of their brains related to those functions.

White matter is made up of the neuronal axons that connect neurons in the "gray matter" brain regions.

Gene Variant May Hike Women's Risk of Alzheimer's

January 12, 2009
Men can carry the variation as well, study finds. Scientists have discovered a gene variant on the X chromosome that appears to increase the risk of developing Alzheimer's disease.

The risk was most pronounced in women with the variant on both X chromosomes, although both women and men with just one variant of the gene were also at greater risk.

"What you have in a nutshell is the first study showing a gene on the X chromosome and the first sex-specific effect [for Alzheimer's]," said Dr.

Antipsychotics Up Death Risk in Alzheimer's Patients

January 09, 2009
Long-term study says the drugs should only be used short-term, as last resort. Alzheimer's patients who are prescribed antipsychotic drugs face a higher risk of death than similar patients not given these medications do, British researchers report.

While the short-term use of antipsychotics has been found to benefit Alzheimer's patients, studies have found that prolonged use can have serious side effects, including Parkinson-like symptoms, sedation, chest infections, decline in brain function, stroke and death.

"It's an eye-opening study since it was one of the few non-company sponsored studies to look at long-term risks," said dementia expert Dr.

9 Genes Are Linked to Alzheimer's

January 07, 2009
Finding also bolsters tie between vitamin D and the brain disease. Researchers have identified nine genes that might make people more likely to develop Alzheimer's disease.

In addition, they confirmed earlier reports that a variation in the vitamin D3 receptor gene, on chromosome 12, might also increase risk for Alzheimer's. Low levels of vitamin D have been found in people with Alzheimer's and other dementias, leading researchers to suspect a link.

Sleep Disorder Could Signal Neurological Disease

December 24, 2008
Finding could help docs spot those at risk for dementia, Parkinsons, researchers say. People with a disorder that causes them to kick or cry out during deep sleep are more likely to develop dementia or Parkinson's disease, a new Canadian study suggests.

"It's basically a disorder where you act out your dreams at night," explained study author Dr. Ronald B.

2 Cardiovascular Proteins Tied to Severity of Alzheimer's

December 22, 2008
Their interaction cuts blood flow to brain, limiting its ability to shed plaques. U.S. researchers have spotted two proteins that deliver a double hit to the brain function of Alzheimer's disease patients.

Not All Dementia Is Called Alzheimer's

December 19, 2008
Vascular cognitive impairment impedes ability to organize thoughts, but it is preventable. A common form of dementia often mistaken for Alzheimer's can be prevented with good health habits, a new report says.

Vascular cognitive impairment (VCI), the second most common cause of dementia, occurs in up to 4 percent of Americans over age 65 and up to 20 percent of those with some form of dementia. Brain damage from multiple small strokes, which can occur from narrowing or blocked arteries in the brain, are often the cause of VCI.

Alzheimer's Drugs Also Treat Behavioral, Psych Problems

December 17, 2008
Therapy effective at same dosage used to improve cognitive impairment, study says. Drugs used to treat Alzheimer's patients' cognitive symptoms are also a safe and effective therapy for behavioral and psychological symptoms such as aggression, wandering and paranoia, according to U.S. researchers.

Scientists ID Enzyme Causing Brain Cell Death

December 10, 2008
Findings could offer new therapies for neurodegenerative diseases. An enzyme believed to play a role in the death of neurons in the brains of patients with Alzheimer's and other neurodegenerative diseases has been identified by U.S. researchers.

Dementia Often Missed as Cause of Death

December 09, 2008
This could skew the truth about deadliness of Alzheimer's, report says. New research suggests that medical officials often fail to record severe dementia as a cause of death in patients with the condition.

This finding not only points to a lack of knowledge about how dementia ..

Study Recruiting From Alzheimer's-Prone Families

November 28, 2008
The findings might boost understanding of the disease generally, researchers say. The adult children of people with the rarer, inherited form of Alzheimer's disease are being sought for a new study to better understand the biology of the brain disorder.

Three hundred adults with a biological parent diagnosed with a known genetic mutation causing the rare, early-onset form of Alzheimer's are needed for the six-year, $16 million study being funded by the U.

When the Caregiver Becomes the Patient

November 20, 2008

Study finds those tending Alzheimer's relatives at risk for hospital visits of their own. The stress of providing care for a loved one with Alzheimer's results in 25 percent of family caregivers having at least one emergency room or hospital visit every six months, says an Indiana University study.

Growth Hormone Boost May Not Slow Alzheimer's

November 19, 2008

A promising approach in mice disappoints in human trial. A compound that boosts growth hormone levels in Alzheimer's patients may not slow the disease, new research suggests.

Ginkgo No Shield Against Alzheimer's

November 18, 2008

Taking the herb long-term didn't prevent or curb dementia, researchers say. Although commonly taken to improve memory, new research suggests that the herb ginkgo biloba won't help prevent dementia, including Alzheimer's disease.

Fewer Brain 'Tangles' May Mean Smarter Old Age

November 17, 2008

Autopsies of quick-witted elderly hint at how they stayed that way.  Differences in the brains of elderly people may help explain why some develop dementia while others are among the "super aged" -- people who maintain sharp mental focus and ability well into old age.

'Cognitive Reserve' May Help Fight Alzheimer's

November 11, 2008

Study sees less damage from brain plaques in those with more education. A study using an advanced brain scanning technology supports the growing body of evidence that education levels and some form of intellectual activity decrease the impact of Alzheimer's disease.

Health Tip

Caring for a Loved One During the Holidays

November 07, 2008

Suggestions to help you and a person with Alzheimer's cope with extra stress Holidays are a time of happiness but they can also be quite stressful, especially for caregivers and their charges with Alzheimer's disease.

Vitamin Holds Promise for Alzheimer's Disease

November 05, 2008

Treatment cured memory problems in mice, researchers found. Researchers report that huge doses of an ordinary vitamin appeared to eliminate memory problems in mice with the rodent equivalent of Alzheimer's disease.

Diabetes, Hypertension Hasten Death in Alzheimer's Patients

November 03, 2008

They're more than twice as likely to die sooner, study finds. Having diabetes or high blood pressure may hasten the death of people with Alzheimer's disease, new research suggests.

Asleep or Awake, Brain Functions the Same

October 31, 2008

Finding may help evaluate infants, as well as psychiatric, movement disorders. The mind functions essentially the same when asleep as when awake, a new study shows.

Epilepsy Drug May Prevent, Treat Alzheimer's

October 30, 2008

Valproic acid blocked formation of brain plaques in mice, Canadian study finds. A drug used to treat epilepsy and bipolar disorder may help prevent and treat Alzheimer's disease, according to Canadian researchers, who found that valproic acid (VPA) blocked the formation of Alzheimer's-related brain plaques in mice.

Scientists Spot 4 New Alzheimer's Genes

October 30, 2008

These DNA may influence age of disease onset and nerve cell death. Four newly identified genes may be linked to the most common form of late-onset Alzheimer's disease, U.S. researchers report.

Job, Education May Buffer Against Dementia

October 21, 2008

Cognitive reserve compensates for brain damage, study says. Having a higher level of education and a mentally demanding job may help protect against the memory loss that precedes Alzheimer's disease, according to an Italian study.

Tests May ID Older Patients at Risk for Post-Op Delirium

October 20, 2008

Underlying depression and less cognitive flexibility could be warning signs, study says. Two simple tests may predict which older patients have underlying depression or less cognitive flexibility, leaving them vulnerable to post-surgery delirium, a new study suggests.

ALS, Alzheimer's Insights Could Improve Treatment

October 20, 2008

But each discovery awaits testing in humans, experts note. New discoveries in amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, and Alzheimer's disease could bring new hope to patients, scientists say.

Aerobics Can Reverse Mental Decline in Older Adults

October 16, 2008

Review of studies shows workouts that leave a person breathless boost brain tissue volume. Regular exercise can reverse age-related brain decline, according to a U.S. cognitive neuroscientist.

Vitamin B No Help for Alzheimer's

October 14, 2008

Reducing homocysteine levels doesn't slow cognitive decline, study finds. Vitamin B supplements don't slow cognitive decline in patients with mild to moderate Alzheimer's disease, a new study finds.

Circadian Rhythm Plays Role in Memory

October 13, 2008

Hamsters deprived of body's sleep-wake system 'can't remember anything,' study says. Your body clock may do more than help guide your daily sleep/wake cycle -- it may also play a vital role in learning and memory, say Stanford University researchers.

Excess Drinking Shrinks the Brain

October 13, 2008

The take-home message is that, if you drink a lot, you're going to hurt your brain," said Rajesh Miranda, an associate professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine. "This is something we knew, but this is a huge study that quantifies that."

Parkinson's Patients More Prone to Vitamin D Deficiency

October 13, 2008

Study found their levels were lower than Alzheimer's patients, healthy controls. Parkinson's disease patients are more likely than healthy people or Alzheimer's patients to have vitamin D deficiency, say researchers from the Emory University School of Medicine in Atlanta.

Occasional Forgetfulness Tied to Loss of Brain Volume

October 06, 2008

It's unclear whether this is linked to dementia, scientists say. Occasionally forget an appointment or a friend's name? Then you may have a loss of brain volume, a new study suggests.

Active Social Life May Reduce Men's Alzheimer's Risk

September 26, 2008

Home, family, club activities appear to enhance creation of new brain cells, study finds. Cognitive and social activity in midlife may significantly reduce men's risk of dementia, says a U.S. study that followed 147 male twin pairs for 28 years.

Scientists ID Compounds That Prevent Brain Nerve Damage

September 25, 2008

Finding could help develop new drugs to treat Alzheimer's, Parkinson's diseases. Duke University Medical Center scientists say they have found compounds that prevented brain injury and greatly improved survival in fruit flies with a Huntington's-like disease.

Simple Blood Test Could Spot Alzheimer's Risk

September 19, 2008

Levels of amyloid beta peptide increase before, decrease after disease presents, study says. A simple blood test to identify people at risk for Alzheimer's disease may be close at hand, according to researchers at Columbia University Medical Center in New York City.

Compound Could Reduce Heart Attack Damage

September 11, 2008

Acts against destructive free radicals, researchers say. A newly developed molecule holds the promise of reducing the damage done by heart attacks and a number of diseases, including Alzheimer's and Parkinson's, researchers report.

Drug Given 24 Hours After Stroke Helps Repair Brain Tissue

September 03, 2008

Bryostatin may also work in patients with Alzheimer's and traumatic injury, study says. A little-used cancer drug called bryostatin can repair brain tissue if it's administered within 24 hours after a stroke, according to U.S. researchers.

Antipsychotic Drugs Boost Stroke Risk

August 29, 2008

And patients with dementia face a more than 3-fold danger, study finds. All antipsychotic drugs can increase the risk of stroke, but the risk is greatest among older patients with dementia, British researchers report.

Scientists Track Hourly Changes in Alzheimer's Protein

August 28, 2008

Recovery from brain injury, not injury itself, associated with increased plaque. A group of researchers has described hourly changes in a protein in the brain that is thought to play a key role in Alzheimer's disease.

Computer-Based Method IDs Alzheimer's Protein Structures

August 22, 2008

Findings hint of new treatments to prevent their formation, MIT study says. A new method of identifying protein structures related to Alzheimer's disease has been developed by researchers at the Massachusetts Institute of Technology.

Cognitive Score Changes Over Time May Hint at Dementia

August 19, 2008

Study authors stress new method is a complement to current testing.  Yearly changes in a person's performance on cognitive testing may be associated with dementia, new research suggests.

Can Physical Cues Signal Dementia?

August 15, 2008

Research suggests that exercise can benefit the brain as well as the body. Memory loss and confusion often provide the first clues to the onset of dementia. But recent research suggests that physical -- not mental -- impairment may be an earlier harbinger of trouble.

Physical Frailty Could Predict Alzheimer's Disease

August 13, 2008

Waning of strength, agility tied to brain damage, even in the absence of dementia. Physical frailty among the elderly may be linked to early Alzheimer's disease, regardless of whether or not patients develop dementia, new research reveals.

PET Scans May Help Detect Alzheimer's Brain Plaques

August 12, 2008

Injectable marker spots deposits, could be used to assess drugs in clinical trials. PET scans may provide doctors with a non-invasive method of detecting Alzheimer's disease-related brain plaques, Finnish researchers say.

Research Links Low HDL Levels With Memory Loss

June 30, 2008

But experts aren't ready to embrace the findings as fact. A new study suggests an association between low levels of "good" HDL cholesterol and loss of memory.

Alzheimer's Drug Shows Early Promise

June 28, 2008

Slowed cognitive decline in patients without ApoE4 gene, trial shows. Long-anticipated results from a trial on an experimental Alzheimer's therapy look promising, at least in a certain group of patients.

Staying Social May Keep Dementia at Bay

June 27, 2008

Study in older women found friends, family helped minds stay sharp. The key to a healthy mind in old age may lie in an active social life, a new study suggests.

Low Childhood IQ Tied to Dementia in Old Age

June 25, 2008
Findings apply to vascular dementia, not Alzheimer's, researchers say.

Gene Variant May Contribute to Alzheimer's Disease

June 25, 2008
The finding could open the door to improved treatments.

Alzheimer's Drug May Reduce Preemie Brain Injury

June 24, 2008
Memantine could protect newborns with compromised blood, oxygen supply, study suggests.

Brain Scans Detect Alzheimer's Disease Quickly

June 24, 2008
New technique could speed the diagnosis, French researchers say.

Alzheimer's Protein Tied to HIV Progression

June 18, 2008
ApoE4 molecule appears to push a faster course of disease, researchers say.

FDA Orders Warning Label on Older Antipsychotics

June 17, 2008
Drugs increase risk of death among elderly patients with dementia, agency says.

New Class of Drugs May Fight Alzheimer's

June 11, 2008
Cousin of some NSAIDS, it could prevent buildup of plaque in the brain, study says.

Sleep Apnea Linked to Memory Loss

June 11, 2008
Study finds disorder shrinks brain cells much the way alcohol, Alzheimer's do.

Adding Light Eases Behavioral Problems of Dementia

June 10, 2008
Study found it fixed circadian rhythms, helped with depression, agitation in elderly.

Green Tea Antioxidant May Help Prevent Alzheimer's

May 30, 2008
The science looks hopeful, but it's still too early to make a dietary recommendation, experts say.

Health Tip

Diet for People With Alzheimer's

May 30, 2008
Help them eat properly

Ibuprofen No Better at Reducing Alzheimer's Risk

May 28, 2008
Aspirin, naproxen as effective, but experts don't endorse use of the drugs to combat dementia.

Study IDs Gene for Late-Onset Alzheimer's

May 28, 2008
Finding could lead to more effective drugs to slow progression of disease.

Antipsychotics Dangerous for Elderly With Dementia

May 27, 2008
Study finds those on drugs more likely to wind up in hospital or die.

Health Tip

Talk to Loved Ones About Your Alzheimer's

May 23, 2008
Share information and feelings with family and friends

Celebrex, Naproxen Won't Prevent Mental Decline

May 12, 2008
New findings suggest daily use of naproxen might even harm cognitive function.

Flavonoids May Help Treat Alzheimer's

May 09, 2008
Compounds found in fruits and vegetables reduced brain plaques in mouse experiments.

Health Tip

Coping With Alzheimer's

May 09, 2008
Keep performing daily tasks

Ibuprofen Linked to Reduced Alzheimer's Risk

May 05, 2008
Other painkillers show some benefit, but more research needed, study says.

Sleep Troubles Vary Between Alzheimer's Patients, Caregivers

May 02, 2008
Their difficulties with slumber are not always connected, researchers say.

Health Tip

Activities for People With Alzheimer's

May 02, 2008
Suggestions to keep busy

Alzheimer's Disease Risk Factors May Be Gender-Specific

May 01, 2008
French study finds depression, stroke key factors in progression toward dementia.

Experimental Drug Eases Symptoms of Mild Alzheimer's

April 30, 2008
Tarenflurbil lessened decline in functional ability, British study concludes.

When It Comes to Memory, It's All About Location

April 25, 2008
Proteasomes that control protein levels could key future treatments for Alzheimer's.

Study Details New Molecular Approach to Preventing Alzheimer's

April 24, 2008
The concept calls for targeting an enzyme within brain cells.

Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia

April 23, 2008
Finding could mean changing animal models used for future research.

Filling in the Alzheimer's 'Race Gap'

April 20, 2008
Black and Hispanics often labor under misconceptions about the disease, researchers discover.

Health Tip

Talking to a Person With Alzheimer's Disease

April 18, 2008
Suggestions to help improve communication

Experimental Alzheimer's Drug Shows Promise

April 17, 2008
Analysis of early study found cognitive function improved in patients.

Men More Likely to Develop Cognitive Problems

April 16, 2008
They face greater risk of losing memory and thinking skills, study finds.

Exercise Could Cut Risk of Mild Cognitive Impairment

April 16, 2008
It may produce chemicals that protect the brain, study suggests.

Smoking, Drinking, Cholesterol May Be Alzheimer's Risk Factors

April 16, 2008
Behaviors in midlife can have an impact decades later, studies suggest.

High Doses of Vitamin E Lengthen Lives of Alzheimer's Patients

April 16, 2008
Study found those who took 2,000 IUs a day lived 26% longer.

Most Early-Onset Dementia Not Alzheimer's

April 15, 2008
Other neurodegenerative, autoimmune diseases are more often cause, study finds.

When a Mind Begins to Disappear

A Young Family's Journey to the Dark Side

April 11, 2008
'I thought Alzheimer's, I thought gray hair,' says Chicago father of 3 who has early-onset version of disease.

Diabetes in Middle Age Raises Alzheimer's Risk

April 09, 2008
Researchers speculate that insulin problems could damage blood vessels in the brain.

Caffeine May Block High Cholesterol Linked to Alzheimer's

April 09, 2008
Its ability to stabilize blood-brain barrier may play role in neurological therapies.

Depression and Alzheimer's Risk Linked

April 07, 2008
But exact nature of the association isn't clear, study finds.

One-Third of Dementia Cases Linked to Small Blood Vessel Damage

April 06, 2008
Findings back control of hypertension, diabetes that may contribute to cumulative effects.

Antipsychotic Drugs of Little Benefit to Alzheimer's Patients

April 02, 2008
They offered some relief, but results were not statistically significant.

With Alzheimer's, It Takes a Family

March 27, 2008
Survey finds children and their children are often involved in caring for loved one.

Abdominal Fat Boosts Dementia Risk

March 26, 2008
Potbellies in midlife may flood brain with toxic substances, researcher says.

Gene Linked to Form of Parkinson's Disease

March 21, 2008
Finding could lead to better understanding of the incurable neurological disorder.

10 Million Baby Boomers Face Alzheimer's, Report Predicts

March 18, 2008
Alzheimer's group says estimate would effectively strain health-care system.

Balance in Old Age Tied to Brain Changes

March 18, 2008
Monitoring white matter levels may assist early identification of walking problems.

1 in 5 U.S. Seniors Struggles With Memory Lapses

March 17, 2008

Some progress to dementia, while others regain their skills, researchers find. More than one-fifth of Americans over age 70 have some memory impairment that isn't classified as dementia, a new study finds.

Health Tip

Early-Stage Alzheimer's

March 13, 2008
How to maintain some independence

Two Parents With Alzheimer's Raises Child's Risk

March 10, 2008
Any additional family history boosts odds of getting the disease earlier, study finds.

Memory Loss in Hyperactive State With Alzheimer's

March 07, 2008
Study suggests brains of patients get stuck in memory-deletion mode

Groups Issue New Dementia Drug Guidelines

March 04, 2008
Review finds little difference in effectiveness of 5 drugs currently available.

Antibiotic Use in Dementia Patients Questioned

February 25, 2008
Benefits are unclear, and resistance to drugs is a worry, study says

Cognitive Impairment Declining in Older Adults

February 20, 2008
Education, wealth play big part in downward trend, study suggests.

Learning Disabilities May Presage Later Language Problems

February 12, 2008
Findings suggest some individuals or families may have underlying speech deficits.

Alzheimer's Plaques Can Form in One Day

February 06, 2008
Study also notes that related neuronal damage follows soon after.

New Guideline Urges Screening for Fall Risk

February 04, 2008
Those with poor balance, dementia, vision loss most in peril, group says.

Alzheimer's Research Target May Be a Dead End

January 28, 2008
Amyloid inhibitors can't prevent brain plaque build-up, study suggests.

Driving Skills Decline Among People With Early Alzheimer's

January 24, 2008
Those with mild dementia had more crashes, almost 4 times more likely to fail road tests.

Older Surgical Patients Face Greater Risk of Cognitive Problems

January 18, 2008
They're also more apt to die within a year, but education had protective effect, study found.

Latest Study Says Statins Don't Slow Alzheimer's

January 17, 2008
Final answer may depend on outcomes of ongoing clinical trials, expert says.

Gene That Creates Cerebral Cortex Discovered

January 17, 2008
Could led to treatments for neurological damage from injuries, disease

Dementia Diagnosis Typically Means Death Within Five Years

January 10, 2008
British study shows age, sex, existing disability can alter timetable.

Fish Oil May Help Prevent Alzheimer's

December 28, 2007
Omega-3 fatty acid boosts protein that destroys brain plaques, study finds

Temporary Amnesia, Confusion Raise Stroke, Dementia Risk

December 26, 2007
Dutch study suggests these lapses need to be taken more seriously.

Regular Walking Protects the Aging Brain

December 19, 2007
Even moderate exercise helps ward off dementia, study shows

A Little Help Can Boost Holiday Joy for Elderly

December 15, 2007
Loved ones can assist them to overcome issues of frailty or mental health, experts say.

Hypertension Linked to Risk of Mild Cognitive Impairment

December 10, 2007
Study suggests it may cause the effect through cerebrovascular disease

Love in the World of Alzheimer's

December 10, 2007
New relationships for those with little memory leave spouses, children facing their own altered reality, experts say.

Aging Brains Get Out of Sync

December 05, 2007
'Senior moments' are typical in later years, study suggests.

Observational Studies Often Overshadow Clinical Research

December 04, 2007
First findings seem to stick, even when controlled trials later contradict them.

High Blood Pressure Could Exacerbate Alzheimer's

November 30, 2007
Slowed blood flow to the brain may be to blame, MRI study shows

Progesterone Won't Shield Women Against Alzheimer's

November 29, 2007
Mouse study shows no benefit for the female hormone

Fish, Fruits, Veggies May Cut Dementia Risk

November 15, 2007
Regular consumption of these foods lowered odds up to 60%, study found

Blacks, Hispanics Live Longer With Alzheimer's

November 14, 2007
Reason for their added survival remains unclear, scientists say.

Long-Term Beta Carotene Use May Protect Against Dementia

November 12, 2007
A beneficial effect was found after at least 15 years, study says.

Blood Pressure, Heartbeat Problems Aggravate Alzheimer's

November 06, 2007
Treating vascular conditions might lessen memory loss, study suggests.

Stem Cells Restore Memory in Mice

October 31, 2007
Experiments point to ways to treat injury, stroke and even Alzheimer's, experts say.

Blood Pressure Drug Might Work Against Alzheimer's

October 25, 2007
It prevents formation of beta-amyloid clumps in mice, study says.

Dementia in More Educated Hits Later But Harder

October 23, 2007
More schooling delayed disease onset, but decline was more rapid afterward, study finds.

Tooth Troubles Could Raise Dementia Risk

October 18, 2007
Fewer teeth in old age linked to mental woes, study finds

Blood Test Might Spot Alzheimer's Early

October 15, 2007
18 proteins ID at-risk patients years before clinical diagnosis, scientists say.

Health Tip

Symptoms of Depression in Alzheimer's Patients

October 12, 2007
May include feeling worthless, not eating

Parkinson's Linked to Risk of Alzheimer's

October 08, 2007
Relatives of Parkinson's patients more likely to develop dementia, study finds.

Alzheimer's Drug Won't Ease Patients' Agitation

October 03, 2007
But Aricept may help stave off cognitive decline, researchers say.

Conscientious People Less Prone to Alzheimer's

October 01, 2007
Living up to your responsibilities may protect brain, study suggests.

Brain Activity Might Point to Early Alzheimer's

September 25, 2007
In future, quick diagnoses should mean better treatment, experts say

Clues to Cell Death Could Fight Disease

September 21, 2007
Insights might produce treatments to kill off cancer cells, experts say

Obesity Won't Affect Seniors' Memory

September 19, 2007
It is tied to increased Alzheimer's risk, however, researchers say

Stem Cells From Testes Produce Wide Range of Tissue Types

September 19, 2007
Work with mice might lead to treatments for diseases such as diabetes and Alzheimer's

Mediterranean Diet May Boost Alzheimer's Survival

September 10, 2007
Patients eating most greens, grains, olive oil lived 4 years longer, study found.

Antidepressant as Good as Antipsychotics for Dementia

September 10, 2007
Study finds fewer side effects for Alzheimer's patients prone to hallucinations, delusions.

Counseling Boosts Alzheimer's Caregivers' Health

September 06, 2007
Spouse study finds it brings the patient real benefit, too

Alzheimer's Patients May Suffer 'Silent' Seizures

September 05, 2007
Mice with similar ailment experienced these subtle attacks, scientists say.

Smokers More Likely to Develop Dementia

September 04, 2007
Tobacco users had a 50% higher risk for Alzheimer's, Dutch study finds

Health Tip

When Alzheimer's Patients Wander

August 30, 2007
Suggestions to help keep them safe

Removing Ovaries Before Menopause Leads to Memory, Movement Troubles

August 29, 2007
Hormone-replacement therapy seems to lessen likelihood of problems, study finds.

Gene Tied to Post-Op Delirium in Elderly

August 24, 2007
APOE e4 variant has also been linked to Alzheimer's, researchers note

Vaccine Stops Alzheimer's Brain 'Tangles'

August 21, 2007
In mouse study, it prevented buildup of dangerous tau protein.

Study Puts 1 Alzheimer's Theory in Doubt

August 20, 2007
Results in mice suggest a key gene might not be to blame, researchers say.

Early Weight Loss in Women Linked to Dementia

August 20, 2007
Study finds a connection, but researchers aren't sure why.

Alzheimer's Protein Implicated in Glaucoma

August 07, 2007
Amyloid-beta appears to destroy retinal cells and may be new treatment target, experts say.

Fish May Ward Off Dementia and Stroke

August 05, 2008

Those rich in omega-3 fatty acids can reduce risk by 26%, study finds. Fish may be brain food after all -- not making you smarter, as your grandmother said, but by lowering the risk of cognitive decline and stroke as you get older, according to a new study.

Being Single in Midlife Could Raise Risk for Dementia Later

July 31, 2008

If you are single and in your 40s, it might be a healthy idea to get hitched. A new Scandinavian study found unmarried middle-aged people are more likely to develop cognitive impairment than their partnered counterparts.

Advances Made Against Alzheimer's Disease

July 31, 2008

 New reports on very different approaches to treating Alzheimer's disease could one day lead to better therapies for the mind-robbing condition, experts say. A trio of studies that were presented Wednesday at the Alzheimer's Association 2008 International Conference on Alzheimer's Disease.

Moms With Alzheimer's May Pass on Risk to Kids

July 30, 2008

People whose mothers have had Alzheimer's disease may be predisposed to the mind-robbing condition, a new study finds. The link may be a dysfunction in how the brain handles sugar.

Family History May Add to Alzheimer's Puzzle

July 30, 2008

The gene most often associated with Alzheimer's disease doesn't provide a complete picture of overall risk, according to researchers who analyzed family histories of the disease.

'De-Tangling' Alzheimer's Drug Shows Promise

July 29, 2008

A drug that aims to reduce the clogging "tangles" in the brain cells of people with Alzheimer's disease appears promising in early trials, researchers report. Further studies are necessary to confirm whether the medication is as effective at slowing Alzheimer's as it seems.

'Biomarkers' May Help Spot, Track Alzheimer's

July 29, 2008

Scientists may be succeeding in the hunt for biomarkers for Alzheimer's disease. A biomarker -- something that can be measured and that gives an indication of what's going on inside the body -- will help in early detection.

Thyroid Hormone May Boost Women's Alzheimer's Risk

July 29, 2008

High or low levels of the hormone thyrotropin may be associated with an increased risk of Alzheimer's disease in women. Thyrotropin affects thyroid gland function and thyroid hormone levels. No association between thyrotropin levels and Alzheimer's risk was noted in men.

Cholesterol-Lowering Drugs Might Help Prevent Alzheimer's

July 28, 2008

Older people who were taking cholesterol-busting statin medications saw their risk for dementia fall by half, a new study found. The finding appears to be more evidence that statins -- which include drugs such as Crestor, Lipitor, Pravachol and Zocor -- can help maintain brain health.

Rates of Mild Cognitive Impairment Higher Than Expected

July 28, 2008

More men, women may develop Alzheimer's than previously thought, researchers say. The growth in the number of cases of mild cognitive impairment in the elderly population is outstripping earlier predictions, Mayo Clinic researchers report.

Alzheimer's Treatment Trials May Have Special Challenges

July 28, 2008

It may be harder to prove the effectiveness of new Alzheimer's disease therapies, because researchers have been having a hard time finding measurable decline in memory and thinking processes in the placebo groups the drugs are being tested against, according to two new reports.

Dementia Underestimated in Developing Countries

July 28, 2008

Rates of dementia in developing countries have been greatly underestimated, according to researchers who used a specially-developed method of calculating dementia prevalence. Previous studies have suggested that rates of dementia in developing countries are much lower than in high-income countries.

Alzheimer's Patients React Poorly to 'Elderspeak'

July 28, 2008

Alzheimer's patients may often become upset and even act out when nurses or other caregivers use "baby talk" to converse with them, a new study shows. Researchers who taped the interactions of nursing home staff and people with moderate Alzheimer's found that the residents often became more agitated and resistant to care if they were addressed as infants

Blood Pressure Drugs May Protect Against Alzheimer's

July 28, 2008

The use of blood pressure drugs called angiotensin receptor blockers (ARBs) is associated with lower incidence and slower progression of Alzheimer's disease, researchers at the Boston University School of Medicine report.

MRI Captures Alzheimer's Lesions

July 28, 2008

Scientists are reporting that they have captured images of brain lesions in rabbits similar to those found in people with Alzheimer's disease using conventional MRIs. Amyloid plaques, which accumulate in the brain and are a hallmark of Alzheimer's.

Most Fit Have Less Brain Atrophy From Alzheimer's

July 28, 2008

Physical fitness can help the mind, body and quality of life of people with early Alzheimer's disease and dementia, according to new research. "These studies reinforce the need for increased awareness and education about the importance of living a brain-healthy lifestyle"

Pet Doors Opening at Assisted Living Centers

July 24, 2008

The health benefits of an animal's companionship can be significant, experts say. When the elderly woman first arrived at Brooke Grove Retirement Village in Sandy Spring, Md., some of the staffers were skeptical when they saw she had brought her cat along.

Mouse Model to Aid Sinusitis Research

July 23, 2008

Genetically engineered rodents will help in study of loss of smell, researcher says. Mice genetically engineered to have inflamed nasal passages may help researchers learn more about loss of smell due to chronic sinusitis.

Memory Problems Tied to Sound Processing Disorder

July 22, 2008

Inability to filter out background noise may be indicator of mild impairment, study says. Mild memory impairment may be associated with a sound processing disorder called central auditory processing dysfunction, say U.S. researchers.

Alzheimer's Research Brings Progress, Setbacks

July 18, 2008

Once-promising vaccine fails to ease symptoms, but old drug offers new hope. In one of two studies in the July 19 issue of The Lancet, an older drug called dimebon significantly improved Alzheimer's symptoms. But in a second report, a once-promising vaccine failed to prevent the progression of Alzheimer's

Exercise Might Slow Brain Shrinkage in Alzheimer's Patients

July 14, 2008

Men and women with early-stage Alzheimer's disease who were more physically fit also had larger brains compared to their counterparts in less stellar shape. The findings, though preliminary, may indicate that staying physically fit could slow the brain atrophy.

More 90-Plus Women Than Men Prone to Dementia

July 02, 2008

But far more women live to be that old, study authors note. Not as many men as women make it to their 90s or beyond, but those who do have an advantage over their female counterparts: Researchers found that males aged 90 and older are more likely to avoid dementia than women of similar age.

Health Tip

Giving Medications to People With Alzheimer's

July 02, 2008

As a caregiver of someone with Alzheimer's, administering their medication -- and preventing missed pills or the wrong dosages -- can be a daunting responsibility. The Alzheimer's Association offers these suggestions.

Mental Test Spots Alzheimer's Risk

July 01, 2008

Questionnaire for those close to patient pinpointed who was likely to progress to dementia.  A new questionnaire may help in both diagnosing older adults facing dementia and also in identifying individuals who need help with daily living.

Diet for People With Alzheimer's

Caring for a person with Alzheimer's disease

May 30, 2008
Caring for a person with Alzheimer's disease often includes helping with all daily activities, including eating.
Here are suggestions to help make mealtime easier, courtesy of the Alzheimer's Association:
Set aside at least an hour for each meal. Don't rush the person through it.


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