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Muscle Weakness Linked to Alzheimer's Risk in Seniors
Researchers at Rush University Medical Center in Chicago followed 970 older adults (average age 80) who didn't have dementia at the start of the study. The participants underwent a number of evaluations, including tests of cognitive function and muscle strength.
Early Use of NSAIDs Might Prevent Alzheimer's
Recent research suggests that the appearance of neuronal cell cycle events (CCEs) occurs early in the development of Alzheimer's. In the new study, U.
High Blood Pressure Likely in Alzheimer's Offspring
Does Diabetes Slow Alzheimer's?
"It's not clear from this study and others what the relationship is," said William Thies, chief medical and scientific officer of the Alzheimer's Association.
What is clear, Thies said, is that having diabetes increases the risk of developing Alzheimer's disease .
Families Need to Know When Dementia Becomes Terminal
The misconception by family members that end-stage dementia is not a terminal condition can have negative consequences for the patient, the researchers say. That's because concerned loved ones often order aggressive, sometimes burdensome interventions such as feeding tubes that will not improve patient outcomes.
Drop in Certain Visual Skills May Precede Alzheimer's
It included 444 people who were dementia-free when they were enrolled in the study and underwent tests on a number of cognitive abilities, including visuospatial skills. The assessments were repeated at least once before the end of the study.
Hairstylists Often Privy to Older Clients' Health Issues
A survey of 40 stylists in the Columbus, Ohio-area found that most develop long-term relationships with their older clients, and these seniors tend to talk freely about their troubles .
Uncertainty Surrounds Testing for Alzheimer's
With a growing array of tests available to predict your odds of developing the degenerative brain disorder .
Dementia Risk Higher for NFL Players
And retired players between the ages of 30 and 49 are 19 times more likely to struggle with memory problems than similarly aged men who never played professional football, the study found.
The findings could have implications that reach far beyond the National Football League, which has said in the past that there's no reliable research to establish the proof of cognitive problems among former players.
Sleep Deprivation Might Lead to Alzheimer's
The research was conducted in mice and is preliminary, and it may not apply to humans. Still, the possible link between sleep deprivation and Alzheimer's raises the prospect of possible treatments that target related pathways in the brain, explained study author Dr.
Preventing Second Stroke May Stave Off Dementia
Two major findings emerged from an analysis of 30 previous studies that involved more than 7,500 people who had suffered a stroke, said Dr. Sarah Pendlebury, a senior clinical fellow at the Stroke Prevention Research Unit of John Radcliffe Hospital in Oxford and lead author of a report published online Sept.
Mishandling Money May Foreshadow Alzheimer's
It included 87 older people with mild cognitive impairment, and 76 others with no memory problems. All the participants took a money management test at the start of the study and again one year later.
Alzheimer's Soars, Global Focus Needed
Study
Older Brains May Not Be So Small After All
A study in the September issue of Neuropsychology examines long-term Dutch research into aging brains, which used neurological tests and MRI scans to measure parts of the brain.
The researchers looked at data from 1994 to 2005 for two groups: 35 people who were cognitively healthy and 30 people who did not have dementia but experienced cognitive decline during the time period.
Trouble With Daily Activities Could Point to Alzheimer's Risk
Alzheimer's Gene Affects Brains of Young Adults
The brains of people in their mid-20s who had the gene variant known as APOE4 .
Cancer Drug May Fight Alzheimer's
The disease, the most common form of dementia among the elderly, is expected to afflict 120 million people worldwide by 2050. Often the first sign is loss of short-term memory.
Even Mild Infections Hasten Decline With Alzheimer's
In this new study, researchers found that Alzheimer's patients who had respiratory, gastrointestinal or other infections .
Trio of Gene Variants Discovered That May Raise Alzheimer's Risk
Teams led by Dr. Philippe Amouyel of the Institut Pasteur de Lille in France, and Julie Williams, a professor of psychological medicine at Cardiff University School of Medicine in Wales, zeroed in on defects in the CLU, CR1 and PICALM genes, and also found another 13 gene variants that are solid candidates for further investigation, according to findings that appear in the Sept.
Health Tip
Keep Seniors Safe at Home
The Alzheimer's Association offers these suggestions:
Make sure the house is equipped with working fire extinguishers, carbon monoxide detectors and smoke detectors.
Keep all hazardous areas locked or blocked, such as the garage or stairs.
As Waistlines Widen, Brains Shrink
That's the message from new research that found that elderly individuals who were obese or overweight had significantly less brain tissue than individuals of normal weight.
"The brains of obese people looked 16 years older than their healthy counterparts while [those of] overweight people looked 8 years older," said UCLA neuroscientist Paul Thompson, senior author of a study published online in Human Brain Mapping.
MRI Might Find Early Alzheimer's
Researchers from the Cleveland Clinic tested 69 mentally healthy adults, two-thirds of whom were at risk for Alzheimer's disease because of family history or genetic markers. Functional MRI was used to monitor the participants' brains as they were asked if they recognized the names of famous celebrities and unfamiliar people.
Mediterranean Diet Plus Exercise Lowers Alzheimer's Risk
The latest research, published in the Aug. 12 issue of the Journal of the American Medical Association, is more evidence that healthy living can help ward off cognitive decline.
Mental Activity Seems to Keep the Brain Vital
Brain-stimulating activity, according to a new study, can delay the rapid loss of memory that precedes dementia.
For five years, researchers followed 488 adults, aged 75 to 85, who did not have dementia at the start of the study.
Special Eye Drops May Reverse Glaucoma Damage
Midlife Heart Risk Factors Linked to Later Dementia
Protein Clumps May Appear Years Before Memory Problems
Previous research had suggested that clumps of amyloid protein, which damage neurons and are characteristic of Alzheimer's disease, begin appearing many years before Alzheimer's symptoms appear. But the link between the deposits and memory impairment had not been clearly demonstrated in humans.
Cellular Protein Yields Clues to Diabetes, Alzheimer's
In tests on rats, they found that humanin, which may prevent nerve cells from dying, also helps improve insulin action and lower blood glucose levels.
"This new role of humanin in glucose metabolism, in addition to its role in Alzheimer's disease, is very intriguing since scientists have long proposed a link between type 2 diabetes and Alzheimer's disease," Dr.
Biomarkers May Predict Alzheimer's
Changes in the chemistry of cerebrospinal fluid have been identified as early signs of Alzheimer's disease. If and when treatments are available for Alzheimer's, diagnosing the disease early may help prevent it from developing, experts say.
New Alzheimer's Treatment Could Be on the Horizon
Researchers looked at the association between the use of intravenous immunoglobulin (IVIg) and the occurrence of Alzheimer's. "IVIg has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer's disease by targeting beta-amyloid, or plaques, in the brain," said Dr.
Signs of Alzheimer's Seen Earlier Than Thought
Unfortunately, scientists don't know of any way to prevent Alzheimer's. But an accompanying study finds that nearly everyone told of their high genetic risk of the disease was glad that they had been informed.
New Treatments for Alzheimer's on the Horizon
A drug called Dimebon seems to improve cognitive function in both mice and humans but, new research reveals, it actually increases brain levels of beta amyloid, a protein long thought to be a leading culprit in the development of Alzheimer's disease.
Meanwhile, a vaccine has had some effect in reducing the number of tau protein tangles that are also associated with Alzheimer's.
Key Protein Might Shield Brain Cells
Healthy Diet, Exercise Keeps Mind Sharp As You Age
That's the recipe for preserving cognitive function as you age, according to four new studies that were presented this week at the Alzheimer's Association annual meeting, in Vienna.
The findings echo other research suggesting that clean living can safeguard mental sharpness.
Dementia Increasing Among the 'Oldest Old'
According to previous epidemiological research, the rate of dementia begins to level off and even decline among people aged 90 and older. But this new study found that the rate of dementia increases with age.
Moderate Drinking Might Guard Against Alzheimer's
Defining "moderate" as having one to two drinks a day, the study authors observed that drinking in this range was associated with a nearly 40 percent drop in dementia risk, compared with non-drinkers.
However, those with a history of even moderate brain health issues did not appear to benefit from any amount of alcohol consumption, and appeared to face a significantly greater risk for dementia in the face of a heavy drinking habit.
Doctors' Attitudes Play Part in Early Alzheimer's Diagnosis
Gene May Help Predict Timing of Alzheimer's Onset
Omega-3 Fatty Acid Falls Short in Alzheimer's Trials
The studies were done because of "a long history of epidemiological studies that related fish consumption to cognitive function," explained Bill Thies, chief medical and scientific officer of the Alzheimer's Association. Fish is rich in DHA, but the research scheduled to be presented Sunday at the association's annual meeting in Vienna, Austria, used DHA derived from algae.
Severe COPD Linked to Mental Decline
Researchers at Mount Sinai School of Medicine in New York City analyzed national data on 4,150 Americans aged 50 and older, including 492 with COPD. Of those, 153 had severe COPD.
Greater Language Skills in 20s May Guard Against Alzheimer's
Also, the brains of women without symptoms of Alzheimer's housed bigger neurons, according to a study appearing in the July 9 online edition of Neurology.
"We noticed that the neurons in this group of people are larger and we also know that the same group of people we call asymptomatic also had higher language skills during their 20s," said study author Dr.
More Evidence That Caffeine Can Jolt Memory
Florida researchers report that a daily dose of 500 milligrams of caffeine .
Living Alone Increases Odds of Developing Dementia
The study included 2,000 men and women in Finland who were initially surveyed when they were about 50 years old and again 21 years later.
Hormones May Affect Neurological Disease Risk
Significant estrogen level changes occur at various stages of women's lives, including adolescence and menopause, and as a result of menstrual cycles. The onset or exacerbation of neurological diseases are most likely to occur at these times, said researchers at the University of Texas Medical Branch.
Statins Might Stave Off Alzheimer's
Scientists have long known that nerve cells in people with Alzheimer's die prematurely because they are strongly overstimulated, a process called excitotoxicity.
Theorizing that the cholesterol drug lovastatin might ward off cell death, researchers at the University of Groningen, The Netherlands, conducted animal experiments in which they administered lovastatin (Altoprev, Mevacor) to overstimulated nerve cells.
Clues to Alzheimer's Spotted Earlier in Disease
University of Gothenburg researchers analyzed cerebrospinal fluid (CSF) samples from 168 patients and found the typical pattern of biomarkers known as the "CSF AD profile" present in patients with mild memory problems, which is earlier than the illness could be detected by current tests.
"The earlier we can catch Alzheimer's disease, the more we can do for the patient," researcher Kaj Blennow said in a university news release.
Stay Upbeat, Active to Keep the Mind Young
Those are the findings of what researchers say is the largest-ever review of studies on aging and the brain.
The review, which spanned three decades and covered more than 400 studies, found that remaining physically, mentally and socially active has a substantial impact on whether older adults experience declines in memory and cognition, which includes the ability to learn and solve problems.
Drug May Stem Slide Into Alzheimer's for Some
But the drug donepezil (Aricept), commonly prescribed for people with Alzheimer's, could slow the depressed person's slide into the disease, the study also found.
The findings are reported in the June 16 issue of Neurology.
Questionnaire May Help Spot Early Dementia
Alzheimer's and Even Mild Dementia Hasten Death
The study, conducted by researchers at Rush University Medical Center in Chicago, contradicts earlier information indicating blacks with Alzheimer's live longer than whites with the disease.
Researchers examined 1,715 older adults with an average age of 80 from four adjacent neighborhoods in Chicago.
Some OTC Sleep, Cold Meds Could Harm Aging Brain
These drugs include Benadryl, Dramamine, Excedrin PM, Nytol, Sominex, Tylenol PM and Unisom.
All of these over-the-counter (OTC) drugs contain benadryl (diphenhydramine), a molecule that blocks the neurotransmitter acetylcholine.
Video May Help People Make End-of-Life Choices
"Medicine is involving patients in a shared decision-making process about their medical care at the end of life," said the study's lead researcher, Dr. Angelo Volandes, from the Department of Medicine at Massachusetts General Hospital in Boston.
Plaques, Tangles in Brain Don't Always Lead to Alzheimer's
In fact, the study found that many people over the age of 75 had signs of significant clogging in their brains but still managed to avoid senility.
The findings don't have immediate ramifications for the treatment of Alzheimer's disease, which remains incurable and only somewhat treatable.
Why Chimps, Monkeys Don't Develop Alzheimer's
Even more inexplicable is the fact that chimpanzee and other non-human primate brains do get clogged with the same protein plaques that are believed by many to cause the disease in humans.
The answer to this puzzle could yield valuable insight into how Alzheimer's develops and progresses, and now researchers report they may have a clue.
Rapid Weight Loss in Seniors Signals Higher Dementia Risk
For older adults, "basically, we saw that if you are thinner or are losing weight at a faster rate, then you are at a higher risk of developing dementia," said study author Tiffany F. Hughes, a postdoctoral fellow in the department of psychiatry at the University of Pittsburgh School of Medicine.
Irregular Heartbeat Tied to Alzheimer's Disease
There are three possible explanations for the relationship, each of which could lead to early treatment aimed at preventing the dementia, said study author Dr. T.
15-Point Test Gauges Alzheimer's Risk
But the tool, which involves both simple questions as well as complex physiological testing, may not be practical for clinical use.
"Some of the points on there are fairly easy, such as age and mental status exams.
Eye Disease, Cognitive Decline Linked in Study
The finding stems from a look at the association between cognitive function decline and the onset of age-related macular degeneration (AMD) among approximately 2,000 Australian seniors between the ages of 69 and 97.
"We found that those who have memory impairment were more likely to have early stages of macular degeneration independent of the effects of age, education and vascular risk factors," said study co-author Dr.
Biomarkers May Help Measure Rate of Decline in Dementia
Science Zeroes In on New Alzheimer's Drug Target
Delirium Episodes Could Hasten Alzheimer's-Linked Decline
Researchers found that people with Alzheimer's who had an episode of delirium while in the hospital had a rate of cognitive decline that was three times faster than that of those who didn't experience delirium.
"From a clinical standpoint, this study suggests that over 12 months, patients with AD [Alzheimer's disease] who become delirious experience the equivalent of an 18-month decline compared to those who do not experience delirium," the study's authors wrote.
U.S. Mental Health Spending Rises, But Many Still Left Out
In a special edition of the May/June issue of Health Affairs focusing on mental health care in the United States, one study found that about half of Americans suffering from mental illness in a given year don't receive treatment, and another 25 percent receive treatment that's not consistent with evidence-based guidelines.
Some patients may receive inappropriate treatments, simply because doctors lack the evidence to make an informed decision about appropriate care, noted Philip Wang, acting deputy director of the National Institute of Mental Health, and colleagues.
Early Alzheimer's Hinders Brain's Effort to Sort Information
Drink Away Dementia?
"Amongst cognitively normal adults, one to two alcoholic drinks a day is associated with a 37 percent decreased risk of dementia over six years," said senior study author Dr. Kaycee Sink, an assistant professor of medicine in geriatrics at the Wake Forest University School of Medicine, in Winston-Salem, N.
Painkillers May Not Protect Against Dementia
"If people are thinking, 'Should I take these to prevent dementia?', the answer based on our study would be no," said study author Dr. Eric B.
Simple Steps to Maintaining Memory
In this case, a study found that older adults improved their memory and certain other mental abilities by playing a video game in which they had to use planning and strategy to take over the world, according to the American Geriatric Society's Foundation for Health in Aging.
Other researchers have found that simply expecting to remember things can help older people recall and recollect and that including carbohydrates in the diet and avoiding multi-tasking can also improve memory.
Newer Antipsychotics May Boost Weight in Alzheimer's Patients
Severe Low Blood Sugar Ups Older Diabetics' Dementia Risk
It's not yet clear whether less severe episodes of low blood sugar, which are more common, are also linked with an increased dementia risk, according to a study in the April 15 issue of the Journal of the American Medical Association, a themed issue on diabetes.
"Hypoglycemic episodes that were severe enough to require hospitalization or an emergency-room visit were associated with a greater risk of dementia, particularly for patients who had multiple episodes.
Brain Cells Give New Clues to Alzheimer's
According to a report in the April 3 issue of Science, researchers at the U.S.
Protein-Folding Problem May Help Spur Alzheimer's
The presence of tangles of misfolded proteins is believed to contribute to Alzheimer's disease, the experts explained. A process known as the "unfolded protein response" typically protects cells from the toxic effects of accumulated misfolded proteins.
With Alzheimer's, Health-Care Costs Could Triple
In addition, people who live in nursing homes or assisted living facilities pay an average of $16,689 in out-of-pocket costs each year, researchers found. The association also estimates that nearly 10 million unpaid caregivers of people with Alzheimer's disease spent 8.
Too Much Red Meat May Shorten Life Span
Alzheimer's Tied to Shrinkage in Brain Area
The research included 64 Alzheimer's patients, 44 people with mild cognitive impairment (the stage of memory problems that occurs before Alzheimer's), and 34 people with no memory or thinking problems. The Dutch team used MRI to measure the volume of the entire brain, as well as the hippocampus, in all the participants at the start of the study and again an average of 18 months later in order to calculate the rate of brain shrinkage.
Alzheimer's Drug May Someday Help Head Trauma Victims
The drugs .
Obesity, Diabetes and Heart Disease May Speed Dementia
Alzheimer's Plaques More Complex Than Thought
Scientists Spot New Clue to Alzheimer's
They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.
"It's been a black box.
Why Music Triggers a Walk Down Memory Lane
The finding, published Feb. 24 in Cerebral Cortex online, might also explain why people with Alzheimer's disease display strong emotional response to songs.
If Parents Had Alzheimer's, Aging May Come Early
This memory decline was not detected in people of middle age whose parents had Alzheimer's but who do not carry the gene, known as ApoE4, according to the study.
About 20 percent to 25 percent of the population have at least one copy of the ApoE4 gene, but not all people with the gene develop Alzheimer's, said study co-author Dr.
Secondhand Smoke Linked to Dementia
While previous research has established a connection between smoking and increased risk for dementia and Alzheimer's disease, this new study is the largest review to date showing a link between secondhand smoke and the threat of dementia, the authors said.
"There is an association between cognitive function, which is often but not necessarily a precursor of dementia, and exposure to passive smoking," said lead researcher Iain Lang, a research fellow in the Public Health and Epidemiology Group at Peninsula Medical School in Exeter, England.
Mediterranean Diet Aids the Aging Brain
Study
Following the healthful diet reduced the risk of getting mild cognitive impairment .
Tests Gauge Alzheimer's Patients' Ability to Drive
Now, new cognitive tests may help doctors determine whether people with the illness are fit to drive.
University of Iowa researchers studied 40 drivers with early Alzheimer's disease and 115 elderly drivers with no diagnosis of dementia.
Brain Protein May Have Potential Against Alzheimer's
The brain's entorhinal cortex, which supports memory, normally produces brain-derived neurotrophic factor (BDNF); however, its production appears to decrease when Alzheimer's is present. When researchers injected BDNF in lab animals that either were aged, had entorhinal cortex damage or were genetically altered to have Alzheimer's-like symptoms, they found that the animals had improved memory and cognitive skills and that cell degeneration and death was prevented or reversed.
Education Doesn't Slow Alzheimer's Decline
The finding contradicts several earlier studies that suggested more education lowered the risk for Alzheimer's disease and dementia.
"Your rate of cognitive decline really doesn't depend on the number of years of schooling you've had," said study author Robert S.
Many Alzheimer's Caregivers Admit to Abusive Behavior
Actual physical abuse was rare, being reported by only three of the 220 caretakers in the study. But the researchers, who published their findings in the Jan.
Moderate Alcohol Consumption May Protect Against Disabilities
The study authors said their research showed that healthy older adults who were light-to-moderate drinkers had 25 percent lower odds of being unable to carry out daily activities such as walking, dressing, eating, running errands or doing chores.
Conversely, heavy drinkers and abstainers had higher risks of disabilities that would limit such activities.
Decide for Me When I Can't, Most People Say
The findings, based on a University of Michigan study, would prove especially helpful in studying people with Alzheimer's disease, which often impairs decision-making ability, making people unable to give proper consent for scientists to study their condition.
The survey of people age 51 and older found that at least 68 percent believed family surrogates should be able to grant consent for a mentally incapacitated loved one to participate in a research study.
Simple Exercise Keeps Brain at Top of Its Game
A study of Canadian women older than 65 found that those who took part in regular aerobic activity had cognitive function scores 10 percent higher than their peers who did not exercise. The active women also had lower blood pressure (at rest and during exercise) and better vascular responses in the brain, suggesting that better blood flow aids the ability to think, the study found.
Positive Outlook Cuts Chances of Dementia
"Older people who are active, outgoing and relaxed may be less likely to develop dementia," said study author Hui-Xin Wang, with the Karolinska Institute in Stockholm, Sweden.
The study, published in the Jan.
Memory Loss Tied to Brain's White Matter
By comparing brain scans of groups of healthy young and old adults, Massachusetts Institute of Technology (MIT) neuroscientists discovered a relationship between loss of memory and cognitive performance in older people and the deterioration of the white matter in the parts of their brains related to those functions.
White matter is made up of the neuronal axons that connect neurons in the "gray matter" brain regions.
Gene Variant May Hike Women's Risk of Alzheimer's
The risk was most pronounced in women with the variant on both X chromosomes, although both women and men with just one variant of the gene were also at greater risk.
"What you have in a nutshell is the first study showing a gene on the X chromosome and the first sex-specific effect [for Alzheimer's]," said Dr.
Antipsychotics Up Death Risk in Alzheimer's Patients
While the short-term use of antipsychotics has been found to benefit Alzheimer's patients, studies have found that prolonged use can have serious side effects, including Parkinson-like symptoms, sedation, chest infections, decline in brain function, stroke and death.
"It's an eye-opening study since it was one of the few non-company sponsored studies to look at long-term risks," said dementia expert Dr.
9 Genes Are Linked to Alzheimer's
In addition, they confirmed earlier reports that a variation in the vitamin D3 receptor gene, on chromosome 12, might also increase risk for Alzheimer's. Low levels of vitamin D have been found in people with Alzheimer's and other dementias, leading researchers to suspect a link.
Sleep Disorder Could Signal Neurological Disease
"It's basically a disorder where you act out your dreams at night," explained study author Dr. Ronald B.
2 Cardiovascular Proteins Tied to Severity of Alzheimer's
Not All Dementia Is Called Alzheimer's
Vascular cognitive impairment (VCI), the second most common cause of dementia, occurs in up to 4 percent of Americans over age 65 and up to 20 percent of those with some form of dementia. Brain damage from multiple small strokes, which can occur from narrowing or blocked arteries in the brain, are often the cause of VCI.
Alzheimer's Drugs Also Treat Behavioral, Psych Problems
Scientists ID Enzyme Causing Brain Cell Death
Dementia Often Missed as Cause of Death
This finding not only points to a lack of knowledge about how dementia ..
Study Recruiting From Alzheimer's-Prone Families
Three hundred adults with a biological parent diagnosed with a known genetic mutation causing the rare, early-onset form of Alzheimer's are needed for the six-year, $16 million study being funded by the U.
When the Caregiver Becomes the Patient
Study finds those tending Alzheimer's relatives at risk for hospital visits of their own. The stress of providing care for a loved one with Alzheimer's results in 25 percent of family caregivers having at least one emergency room or hospital visit every six months, says an Indiana University study.
Growth Hormone Boost May Not Slow Alzheimer's
A promising approach in mice disappoints in human trial. A compound that boosts growth hormone levels in Alzheimer's patients may not slow the disease, new research suggests.
Ginkgo No Shield Against Alzheimer's
Taking the herb long-term didn't prevent or curb dementia, researchers say. Although commonly taken to improve memory, new research suggests that the herb ginkgo biloba won't help prevent dementia, including Alzheimer's disease.
Fewer Brain 'Tangles' May Mean Smarter Old Age
Autopsies of quick-witted elderly hint at how they stayed that way. Differences in the brains of elderly people may help explain why some develop dementia while others are among the "super aged" -- people who maintain sharp mental focus and ability well into old age.
'Cognitive Reserve' May Help Fight Alzheimer's
Study sees less damage from brain plaques in those with more education. A study using an advanced brain scanning technology supports the growing body of evidence that education levels and some form of intellectual activity decrease the impact of Alzheimer's disease.
Health Tip
Caring for a Loved One During the Holidays
Suggestions to help you and a person with Alzheimer's cope with extra stress Holidays are a time of happiness but they can also be quite stressful, especially for caregivers and their charges with Alzheimer's disease.
Vitamin Holds Promise for Alzheimer's Disease
Treatment cured memory problems in mice, researchers found. Researchers report that huge doses of an ordinary vitamin appeared to eliminate memory problems in mice with the rodent equivalent of Alzheimer's disease.
Diabetes, Hypertension Hasten Death in Alzheimer's Patients
They're more than twice as likely to die sooner, study finds. Having diabetes or high blood pressure may hasten the death of people with Alzheimer's disease, new research suggests.
Asleep or Awake, Brain Functions the Same
Finding may help evaluate infants, as well as psychiatric, movement disorders. The mind functions essentially the same when asleep as when awake, a new study shows.
Epilepsy Drug May Prevent, Treat Alzheimer's
Valproic acid blocked formation of brain plaques in mice, Canadian study finds. A drug used to treat epilepsy and bipolar disorder may help prevent and treat Alzheimer's disease, according to Canadian researchers, who found that valproic acid (VPA) blocked the formation of Alzheimer's-related brain plaques in mice.
Scientists Spot 4 New Alzheimer's Genes
These DNA may influence age of disease onset and nerve cell death. Four newly identified genes may be linked to the most common form of late-onset Alzheimer's disease, U.S. researchers report.
Job, Education May Buffer Against Dementia
Cognitive reserve compensates for brain damage, study says. Having a higher level of education and a mentally demanding job may help protect against the memory loss that precedes Alzheimer's disease, according to an Italian study.
Tests May ID Older Patients at Risk for Post-Op Delirium
Underlying depression and less cognitive flexibility could be warning signs, study says. Two simple tests may predict which older patients have underlying depression or less cognitive flexibility, leaving them vulnerable to post-surgery delirium, a new study suggests.
ALS, Alzheimer's Insights Could Improve Treatment
But each discovery awaits testing in humans, experts note. New discoveries in amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, and Alzheimer's disease could bring new hope to patients, scientists say.
Aerobics Can Reverse Mental Decline in Older Adults
Review of studies shows workouts that leave a person breathless boost brain tissue volume. Regular exercise can reverse age-related brain decline, according to a U.S. cognitive neuroscientist.
Vitamin B No Help for Alzheimer's
Reducing homocysteine levels doesn't slow cognitive decline, study finds. Vitamin B supplements don't slow cognitive decline in patients with mild to moderate Alzheimer's disease, a new study finds.
Circadian Rhythm Plays Role in Memory
Hamsters deprived of body's sleep-wake system 'can't remember anything,' study says. Your body clock may do more than help guide your daily sleep/wake cycle -- it may also play a vital role in learning and memory, say Stanford University researchers.
Excess Drinking Shrinks the Brain
The take-home message is that, if you drink a lot, you're going to hurt your brain," said Rajesh Miranda, an associate professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine. "This is something we knew, but this is a huge study that quantifies that."
Parkinson's Patients More Prone to Vitamin D Deficiency
Study found their levels were lower than Alzheimer's patients, healthy controls. Parkinson's disease patients are more likely than healthy people or Alzheimer's patients to have vitamin D deficiency, say researchers from the Emory University School of Medicine in Atlanta.
Occasional Forgetfulness Tied to Loss of Brain Volume
It's unclear whether this is linked to dementia, scientists say. Occasionally forget an appointment or a friend's name? Then you may have a loss of brain volume, a new study suggests.
Active Social Life May Reduce Men's Alzheimer's Risk
Home, family, club activities appear to enhance creation of new brain cells, study finds. Cognitive and social activity in midlife may significantly reduce men's risk of dementia, says a U.S. study that followed 147 male twin pairs for 28 years.
Scientists ID Compounds That Prevent Brain Nerve Damage
Finding could help develop new drugs to treat Alzheimer's, Parkinson's diseases. Duke University Medical Center scientists say they have found compounds that prevented brain injury and greatly improved survival in fruit flies with a Huntington's-like disease.
Simple Blood Test Could Spot Alzheimer's Risk
Levels of amyloid beta peptide increase before, decrease after disease presents, study says. A simple blood test to identify people at risk for Alzheimer's disease may be close at hand, according to researchers at Columbia University Medical Center in New York City.
Compound Could Reduce Heart Attack Damage
Acts against destructive free radicals, researchers say. A newly developed molecule holds the promise of reducing the damage done by heart attacks and a number of diseases, including Alzheimer's and Parkinson's, researchers report.
Drug Given 24 Hours After Stroke Helps Repair Brain Tissue
Bryostatin may also work in patients with Alzheimer's and traumatic injury, study says. A little-used cancer drug called bryostatin can repair brain tissue if it's administered within 24 hours after a stroke, according to U.S. researchers.
Antipsychotic Drugs Boost Stroke Risk
And patients with dementia face a more than 3-fold danger, study finds. All antipsychotic drugs can increase the risk of stroke, but the risk is greatest among older patients with dementia, British researchers report.
Scientists Track Hourly Changes in Alzheimer's Protein
Recovery from brain injury, not injury itself, associated with increased plaque. A group of researchers has described hourly changes in a protein in the brain that is thought to play a key role in Alzheimer's disease.
Computer-Based Method IDs Alzheimer's Protein Structures
Findings hint of new treatments to prevent their formation, MIT study says. A new method of identifying protein structures related to Alzheimer's disease has been developed by researchers at the Massachusetts Institute of Technology.
Cognitive Score Changes Over Time May Hint at Dementia
Study authors stress new method is a complement to current testing. Yearly changes in a person's performance on cognitive testing may be associated with dementia, new research suggests.
Can Physical Cues Signal Dementia?
Research suggests that exercise can benefit the brain as well as the body. Memory loss and confusion often provide the first clues to the onset of dementia. But recent research suggests that physical -- not mental -- impairment may be an earlier harbinger of trouble.
Physical Frailty Could Predict Alzheimer's Disease
Waning of strength, agility tied to brain damage, even in the absence of dementia. Physical frailty among the elderly may be linked to early Alzheimer's disease, regardless of whether or not patients develop dementia, new research reveals.
PET Scans May Help Detect Alzheimer's Brain Plaques
Injectable marker spots deposits, could be used to assess drugs in clinical trials. PET scans may provide doctors with a non-invasive method of detecting Alzheimer's disease-related brain plaques, Finnish researchers say.
Research Links Low HDL Levels With Memory Loss
But experts aren't ready to embrace the findings as fact. A new study suggests an association between low levels of "good" HDL cholesterol and loss of memory.
Alzheimer's Drug Shows Early Promise
Slowed cognitive decline in patients without ApoE4 gene, trial shows. Long-anticipated results from a trial on an experimental Alzheimer's therapy look promising, at least in a certain group of patients.
Staying Social May Keep Dementia at Bay
Study in older women found friends, family helped minds stay sharp. The key to a healthy mind in old age may lie in an active social life, a new study suggests.
Low Childhood IQ Tied to Dementia in Old Age
Gene Variant May Contribute to Alzheimer's Disease
Alzheimer's Drug May Reduce Preemie Brain Injury
Brain Scans Detect Alzheimer's Disease Quickly
Alzheimer's Protein Tied to HIV Progression
FDA Orders Warning Label on Older Antipsychotics
New Class of Drugs May Fight Alzheimer's
Sleep Apnea Linked to Memory Loss
Adding Light Eases Behavioral Problems of Dementia
Green Tea Antioxidant May Help Prevent Alzheimer's
Ibuprofen No Better at Reducing Alzheimer's Risk
Study IDs Gene for Late-Onset Alzheimer's
Antipsychotics Dangerous for Elderly With Dementia
Health Tip
Talk to Loved Ones About Your Alzheimer's
Celebrex, Naproxen Won't Prevent Mental Decline
Flavonoids May Help Treat Alzheimer's
Ibuprofen Linked to Reduced Alzheimer's Risk
Sleep Troubles Vary Between Alzheimer's Patients, Caregivers
Alzheimer's Disease Risk Factors May Be Gender-Specific
Experimental Drug Eases Symptoms of Mild Alzheimer's
When It Comes to Memory, It's All About Location
Study Details New Molecular Approach to Preventing Alzheimer's
Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia
Filling in the Alzheimer's 'Race Gap'
Health Tip
Talking to a Person With Alzheimer's Disease
Experimental Alzheimer's Drug Shows Promise
Men More Likely to Develop Cognitive Problems
Exercise Could Cut Risk of Mild Cognitive Impairment
Smoking, Drinking, Cholesterol May Be Alzheimer's Risk Factors
High Doses of Vitamin E Lengthen Lives of Alzheimer's Patients
Most Early-Onset Dementia Not Alzheimer's
When a Mind Begins to Disappear
A Young Family's Journey to the Dark Side
Diabetes in Middle Age Raises Alzheimer's Risk
Caffeine May Block High Cholesterol Linked to Alzheimer's
Depression and Alzheimer's Risk Linked
One-Third of Dementia Cases Linked to Small Blood Vessel Damage
Antipsychotic Drugs of Little Benefit to Alzheimer's Patients
With Alzheimer's, It Takes a Family
Abdominal Fat Boosts Dementia Risk
Gene Linked to Form of Parkinson's Disease
10 Million Baby Boomers Face Alzheimer's, Report Predicts
Balance in Old Age Tied to Brain Changes
1 in 5 U.S. Seniors Struggles With Memory Lapses
Some progress to dementia, while others regain their skills, researchers find. More than one-fifth of Americans over age 70 have some memory impairment that isn't classified as dementia, a new study finds.
Two Parents With Alzheimer's Raises Child's Risk
Memory Loss in Hyperactive State With Alzheimer's
Groups Issue New Dementia Drug Guidelines
Antibiotic Use in Dementia Patients Questioned
Cognitive Impairment Declining in Older Adults
Learning Disabilities May Presage Later Language Problems
Alzheimer's Plaques Can Form in One Day
New Guideline Urges Screening for Fall Risk
Alzheimer's Research Target May Be a Dead End
Driving Skills Decline Among People With Early Alzheimer's
Older Surgical Patients Face Greater Risk of Cognitive Problems
Latest Study Says Statins Don't Slow Alzheimer's
Gene That Creates Cerebral Cortex Discovered
Dementia Diagnosis Typically Means Death Within Five Years
Fish Oil May Help Prevent Alzheimer's
Temporary Amnesia, Confusion Raise Stroke, Dementia Risk
Regular Walking Protects the Aging Brain
A Little Help Can Boost Holiday Joy for Elderly
Hypertension Linked to Risk of Mild Cognitive Impairment
Love in the World of Alzheimer's
Aging Brains Get Out of Sync
Observational Studies Often Overshadow Clinical Research
High Blood Pressure Could Exacerbate Alzheimer's
Progesterone Won't Shield Women Against Alzheimer's
Fish, Fruits, Veggies May Cut Dementia Risk
Blacks, Hispanics Live Longer With Alzheimer's
Long-Term Beta Carotene Use May Protect Against Dementia
Blood Pressure, Heartbeat Problems Aggravate Alzheimer's
Stem Cells Restore Memory in Mice
Blood Pressure Drug Might Work Against Alzheimer's
Dementia in More Educated Hits Later But Harder
Tooth Troubles Could Raise Dementia Risk
Blood Test Might Spot Alzheimer's Early
Health Tip
Symptoms of Depression in Alzheimer's Patients
Parkinson's Linked to Risk of Alzheimer's
Alzheimer's Drug Won't Ease Patients' Agitation
Conscientious People Less Prone to Alzheimer's
Brain Activity Might Point to Early Alzheimer's
Clues to Cell Death Could Fight Disease
Obesity Won't Affect Seniors' Memory
Stem Cells From Testes Produce Wide Range of Tissue Types
Mediterranean Diet May Boost Alzheimer's Survival
Antidepressant as Good as Antipsychotics for Dementia
Counseling Boosts Alzheimer's Caregivers' Health
Alzheimer's Patients May Suffer 'Silent' Seizures
Smokers More Likely to Develop Dementia
Removing Ovaries Before Menopause Leads to Memory, Movement Troubles
Gene Tied to Post-Op Delirium in Elderly
Vaccine Stops Alzheimer's Brain 'Tangles'
Study Puts 1 Alzheimer's Theory in Doubt
Early Weight Loss in Women Linked to Dementia
Alzheimer's Protein Implicated in Glaucoma
Fish May Ward Off Dementia and Stroke
Those rich in omega-3 fatty acids can reduce risk by 26%, study finds. Fish may be brain food after all -- not making you smarter, as your grandmother said, but by lowering the risk of cognitive decline and stroke as you get older, according to a new study.
Being Single in Midlife Could Raise Risk for Dementia Later
If you are single and in your 40s, it might be a healthy idea to get hitched. A new Scandinavian study found unmarried middle-aged people are more likely to develop cognitive impairment than their partnered counterparts.
Advances Made Against Alzheimer's Disease
New reports on very different approaches to treating Alzheimer's disease could one day lead to better therapies for the mind-robbing condition, experts say. A trio of studies that were presented Wednesday at the Alzheimer's Association 2008 International Conference on Alzheimer's Disease.
Moms With Alzheimer's May Pass on Risk to Kids
People whose mothers have had Alzheimer's disease may be predisposed to the mind-robbing condition, a new study finds. The link may be a dysfunction in how the brain handles sugar.
Family History May Add to Alzheimer's Puzzle
The gene most often associated with Alzheimer's disease doesn't provide a complete picture of overall risk, according to researchers who analyzed family histories of the disease.
'De-Tangling' Alzheimer's Drug Shows Promise
A drug that aims to reduce the clogging "tangles" in the brain cells of people with Alzheimer's disease appears promising in early trials, researchers report. Further studies are necessary to confirm whether the medication is as effective at slowing Alzheimer's as it seems.
'Biomarkers' May Help Spot, Track Alzheimer's
Scientists may be succeeding in the hunt for biomarkers for Alzheimer's disease. A biomarker -- something that can be measured and that gives an indication of what's going on inside the body -- will help in early detection.
Thyroid Hormone May Boost Women's Alzheimer's Risk
High or low levels of the hormone thyrotropin may be associated with an increased risk of Alzheimer's disease in women. Thyrotropin affects thyroid gland function and thyroid hormone levels. No association between thyrotropin levels and Alzheimer's risk was noted in men.
Cholesterol-Lowering Drugs Might Help Prevent Alzheimer's
Older people who were taking cholesterol-busting statin medications saw their risk for dementia fall by half, a new study found. The finding appears to be more evidence that statins -- which include drugs such as Crestor, Lipitor, Pravachol and Zocor -- can help maintain brain health.
Rates of Mild Cognitive Impairment Higher Than Expected
More men, women may develop Alzheimer's than previously thought, researchers say. The growth in the number of cases of mild cognitive impairment in the elderly population is outstripping earlier predictions, Mayo Clinic researchers report.
Alzheimer's Treatment Trials May Have Special Challenges
It may be harder to prove the effectiveness of new Alzheimer's disease therapies, because researchers have been having a hard time finding measurable decline in memory and thinking processes in the placebo groups the drugs are being tested against, according to two new reports.
Dementia Underestimated in Developing Countries
Rates of dementia in developing countries have been greatly underestimated, according to researchers who used a specially-developed method of calculating dementia prevalence. Previous studies have suggested that rates of dementia in developing countries are much lower than in high-income countries.
Alzheimer's Patients React Poorly to 'Elderspeak'
Alzheimer's patients may often become upset and even act out when nurses or other caregivers use "baby talk" to converse with them, a new study shows. Researchers who taped the interactions of nursing home staff and people with moderate Alzheimer's found that the residents often became more agitated and resistant to care if they were addressed as infants
Blood Pressure Drugs May Protect Against Alzheimer's
The use of blood pressure drugs called angiotensin receptor blockers (ARBs) is associated with lower incidence and slower progression of Alzheimer's disease, researchers at the Boston University School of Medicine report.
MRI Captures Alzheimer's Lesions
Scientists are reporting that they have captured images of brain lesions in rabbits similar to those found in people with Alzheimer's disease using conventional MRIs. Amyloid plaques, which accumulate in the brain and are a hallmark of Alzheimer's.
Most Fit Have Less Brain Atrophy From Alzheimer's
Physical fitness can help the mind, body and quality of life of people with early Alzheimer's disease and dementia, according to new research. "These studies reinforce the need for increased awareness and education about the importance of living a brain-healthy lifestyle"
Pet Doors Opening at Assisted Living Centers
The health benefits of an animal's companionship can be significant, experts say. When the elderly woman first arrived at Brooke Grove Retirement Village in Sandy Spring, Md., some of the staffers were skeptical when they saw she had brought her cat along.
Mouse Model to Aid Sinusitis Research
Genetically engineered rodents will help in study of loss of smell, researcher says. Mice genetically engineered to have inflamed nasal passages may help researchers learn more about loss of smell due to chronic sinusitis.
Memory Problems Tied to Sound Processing Disorder
Inability to filter out background noise may be indicator of mild impairment, study says. Mild memory impairment may be associated with a sound processing disorder called central auditory processing dysfunction, say U.S. researchers.
Alzheimer's Research Brings Progress, Setbacks
Once-promising vaccine fails to ease symptoms, but old drug offers new hope. In one of two studies in the July 19 issue of The Lancet, an older drug called dimebon significantly improved Alzheimer's symptoms. But in a second report, a once-promising vaccine failed to prevent the progression of Alzheimer's
Exercise Might Slow Brain Shrinkage in Alzheimer's Patients
Men and women with early-stage Alzheimer's disease who were more physically fit also had larger brains compared to their counterparts in less stellar shape. The findings, though preliminary, may indicate that staying physically fit could slow the brain atrophy.
More 90-Plus Women Than Men Prone to Dementia
But far more women live to be that old, study authors note. Not as many men as women make it to their 90s or beyond, but those who do have an advantage over their female counterparts: Researchers found that males aged 90 and older are more likely to avoid dementia than women of similar age.
Health Tip
Giving Medications to People With Alzheimer's
As a caregiver of someone with Alzheimer's, administering their medication -- and preventing missed pills or the wrong dosages -- can be a daunting responsibility. The Alzheimer's Association offers these suggestions.
Mental Test Spots Alzheimer's Risk
Questionnaire for those close to patient pinpointed who was likely to progress to dementia. A new questionnaire may help in both diagnosing older adults facing dementia and also in identifying individuals who need help with daily living.
Diet for People With Alzheimer's
Caring for a person with Alzheimer's disease
Here are suggestions to help make mealtime easier, courtesy of the Alzheimer's Association:
Set aside at least an hour for each meal. Don't rush the person through it.





